Results 201 to 210 of about 11,717,609 (299)

A Novel Approach to the Design and Sample Size Planning of Animal Experiments Based on Effect Estimation. [PDF]

Biom J
Zocholl D, Solveen H, Schmid M.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A Tutorial on Sample Size Calculation for Inter-rater and Intra-rater Agreement Studies. [PDF]

Indian J Psychol Med
Madadizadeh F, Bahariniya S.
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Substituting blood-based biomarkers for imaging measures in Alzheimer's disease studies: implications for sample size and bias. [PDF]

J Gerontol A Biol Sci Med Sci
Ackley SF, La Joie R, Caunca M, Mukherjee S, Choi SE, Trittschuh EH, Crane PK, Hayes-Larson E, Alzheimer’s Disease Neuroimaging Initiative.   +8 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Sample Size Determination for Pilot Studies Based on Event Thresholds: A Framework for Evaluating Feasibility of Research Processes. [PDF]

Indian J Psychol Med
Bujang MA.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A digital twin methodology using retrospective patient data for sample size reduction in Alzheimer's disease clinical trials. [PDF]

Alzheimers Res Ther
Andrews D, Golchi S, Collins DL, Alzheimer’s Disease Neuroimaging Initiative.   +3 more
europepmc   +1 more source