Results 111 to 120 of about 1,987,342 (275)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Sample sizes for the SF-6D preference based measure of health from the SF-36: a practical guide [PDF]
Background Health Related Quality of Life (HRQoL) measures are becoming more frequently used in clinical trials and health services research, both as primary and secondary endpoints.
Brazier, JE, Walters, SJ
core +1 more source
The power of sample size calculations
European Journal of EndocrinologyAbstract Researchers frequently come across sample size calculations in the scientific literature they read, in projects undertaken by their peers, and likely within their own work. However, despite its ubiquity, calculating a sample size is often perceived as a hurdle and not fully understood.
Marieke S Jansen +2 more
openaire +3 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Reply to: Analysis of covariance and sample size calculation for comparing means in randomized controlled trials. [PDF]
J Cardiovasc Thorac Res, 2023 Mesri Alamdari N +2 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
PRACTICAL METHODS OF SELECTION AND CALCULATION OF SAMPLE SIZE FOR AUDIT SAMPLING [PDF]
Challenges of the Knowledge Society, 2019 Audit sampling is very important part of audit works. No mater it is financial audit, internal audit and others kind of audit, audit sampling still need to be used by auditors.
Sandra TEODORESCU, Andreea Paula DUMITRU
doaj
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Randomized Phase II Cancer Clinical Trials to Validate Predictive Biomarkers
BiomedicinesObjectives: The design of cancer clinical trials incorporating biomarkers depends on various factors, including the trial phase, the type of biomarker and whether its role has been validated.
Baoshan Zhang +3 more
doaj +1 more source
artcat: Sample-size calculation for an ordered categorical outcome. [PDF]
Stata J, 2023 White IR +5 more
europepmc +1 more source