Results 221 to 230 of about 1,987,342 (275)
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
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Simple sample size calculation
Journal of Evaluation in Clinical Practice, 2007© 2007 The Authors. Journal compilation © 2007 Blackwell Publishing Ltd, Journal of Evaluation in Clinical Practice 13 (2007) 952–953 Journal of Evaluation in Clinical Practice ISSN 1356-1294 Blackwell Publishing LtdOxford, UKJEPJournal of Evaluation in Clinical Practice1356 1294© 2006 The Authors; Journal compilation © 2006 Blackwell Publishing ...
David J, Torgerson, Jeremy N V, Miles
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BMJ, 2010
A randomised controlled trial investigated whether a computerised feedback device modified eating behaviour and resulted in weight loss in obese adolescents.1 The primary outcome was change in body mass index (BMI) from recruitment to 12 months. BMI was calculated as weight (kg)/[height (m)]2, adjusted for age and sex.
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A randomised controlled trial investigated whether a computerised feedback device modified eating behaviour and resulted in weight loss in obese adolescents.1 The primary outcome was change in body mass index (BMI) from recruitment to 12 months. BMI was calculated as weight (kg)/[height (m)]2, adjusted for age and sex.
openaire +3 more sources
2017
Expanding on the discussion of sample size as noted in Chap. 14, this chapter covers the importance of sample size estimation in clinical trials involving invasive operative and nonoperative procedures. It focuses on the key elements for sample size determination that includes acquiring a reliable estimate of the treatment effect and variability, the ...
Eileen M. Stock, Kousick Biswas
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Expanding on the discussion of sample size as noted in Chap. 14, this chapter covers the importance of sample size estimation in clinical trials involving invasive operative and nonoperative procedures. It focuses on the key elements for sample size determination that includes acquiring a reliable estimate of the treatment effect and variability, the ...
Eileen M. Stock, Kousick Biswas
openaire +1 more source
The American Statistician, 2003
Conventionally, sample size calculations are viewed as calculations determining the right number of subjects needed for a study. Such calculations follow the classical paradigm: for a difference X, I need sample size Y. We argue that the paradigm for a sample size Y, I get information Z is more appropriate for many studies and reflects the information ...
Parker R.A., Berman N.G.
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Conventionally, sample size calculations are viewed as calculations determining the right number of subjects needed for a study. Such calculations follow the classical paradigm: for a difference X, I need sample size Y. We argue that the paradigm for a sample size Y, I get information Z is more appropriate for many studies and reflects the information ...
Parker R.A., Berman N.G.
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2016
Just like with continuous outcome data (Chap. 12), with binary outcome data an essential part of the study protocol is the assessment of the question, how many subject need to be studied in order to answer the studies’ objectives. This chapter provides equations that can be used for the purpose if your outcome data are binary.
Ton J. Cleophas, Aeilko H. Zwinderman
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Just like with continuous outcome data (Chap. 12), with binary outcome data an essential part of the study protocol is the assessment of the question, how many subject need to be studied in order to answer the studies’ objectives. This chapter provides equations that can be used for the purpose if your outcome data are binary.
Ton J. Cleophas, Aeilko H. Zwinderman
openaire +1 more source