Results 111 to 120 of about 701,480 (245)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Sample size determination for the association between longitudinal and time-to-event outcomes using the joint modeling time-dependent slopes parameterization. [PDF]
Stat Med, 2022 LeClair J +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
پژوهشهای ریاضی, 2018 Introduction Longitudinal study designs are common in a lot of scientific researches, especially in medical, social and economic sciences. The reason is that longitudinal studies allow researchers to measure changes of each individual over time and often
Taban Baghfalaki
doaj
Bayesian sample size determination using commensurate priors to leverage pre-experimental data. [PDF]
Biometrics, 2022 Zheng H, Jaki T, Wason JMS.
europepmc +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
A Step-by-Step Process on Sample Size Determination for Medical Research. [PDF]
Malays J Med Sci, 2021 Bujang MA.
europepmc +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Sample Size Determination for Interval Estimation of the Prevalence of a Sensitive Attribute Under Randomized Response Models. [PDF]
Psychometrika, 2022 Qiu SF, Tang ML, Tao JR, Wong RS.
europepmc +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source