Results 141 to 150 of about 3,758,239 (336)

Determination of minimum sample size and discriminatory expression patterns in microarray data [PDF]

, 2002
Daehee Hwang, William A. Schmitt, George Stephanopoulos, Gregory Stephanopoulos   +3 more
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Sample size determination for external pilot cluster randomised trials with binary feasibility outcomes: a tutorial. [PDF]

Pilot Feasibility Stud, 2023
Hemming K, Taljaard M, Gkini E, Bishop J.   +3 more
europepmc   +1 more source

Determination of Optimal Spatial Sample Sizes for Fitting Negative Binomial-Based Crash Prediction Models with Consideration of Statistical Modeling Assumptions

, 2023
Mohammadreza Koloushani, Seyed Reza Abazari, O. Arda Vanli, Eren Erman Özgüven, Ren Moses, Rupert Giroux, Benjamin Jacobs   +6 more
openalex   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Practical approaches to Bayesian sample size determination in non-inferiority trials with binary outcomes. [PDF]

Stat Med, 2023
Turner RM, Clements MN, Quartagno M, Cornelius V, Cro S, Ford D, Tweed CD, Walker AS, White IR.   +8 more
europepmc   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Determination of sample size for a multinomial model coupled with the phenology model

Frontiers in Applied Mathematics and Statistics
Predicting the timing of phenological events is important in agriculture, especially high-revenue products. A project sponsored by USDA-ARS had the objective of adapting a previously developed model for estimating proportions of insects in different ...
Martyna Lukaszewicz, Brian Dennis, Brian Dennis   +2 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Using Bayesian statistics in confirmatory clinical trials in the regulatory setting: a tutorial review

BMC Medical Research Methodology
Bayesian statistics plays a pivotal role in advancing medical science by enabling healthcare companies, regulators, and stakeholders to assess the safety and efficacy of new treatments, interventions, and medical procedures. The Bayesian framework offers
Se Yoon Lee
doaj   +1 more source