Results 151 to 160 of about 3,758,239 (336)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Sample size determination and evaluation for two-stage adaptive designs of single arm clinical trials based on median event time test. [PDF]

Contemp Clin Trials Commun, 2023
Park Y, Chen Y.
europepmc   +1 more source

Two-Stage Design Sample Size Determination for Two Doses in Oncology Phase II Trials [PDF]

Meiruo Xiang, Yangruijue Ma, Qian Li
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Determination of Sample Size

The Malaysian journal of medical sciences : MJMS, 2013
There is a particular importance of determining a basic minimum required 'n' size of the sample to recognize a particular measurement of a particular population. This article has highlighted the determination of an appropriate size to estimate population parameters.
openaire   +3 more sources

SAMPLE SIZE DETERMINATION IN NON-RADOMIZED SURVIVAL STUDIES WITH NON-CENSORED AND CENSORED DATA

Journal of Research in Medical Sciences, 2003
Introduction: In survival analysis, determination of sufficient sample size to achieve suitable statistical power is important .In both parametric and non-parametric methods of classic statistics, randomn selection of samples is a basic condition ...
S FAGHIHZADEH, M RAHGOZAR
doaj  

Bayesian sample size determination for diagnostic accuracy studies. [PDF]

Stat Med, 2022
Wilson KJ, Williamson SF, Allen AJ, Williams CJ, Hellyer TP, Lendrem BC.   +5 more
europepmc   +1 more source

Determination of appropriate grid dimension and sampling plot size for assessment of woody species diversity in Zagros Forest, Iran

, 1970
A. A. Zohrevandi, Hassan Pourbabaei, Reza Akhavan, Amir Eslam Bonyad   +3 more
openalex   +1 more source

General purpose computer program for interacting supersonic configurations. User's manual [PDF]

The input data required to execute the computer program ISCON are described. The program generates a numerical procedure for the determination of unsteady aerodynamic forces on arbitrarily interacting wings and tails in supersonic flow.
Crill, W., Dale, B.
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source