Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Bayesian approach for sample size determination, illustrated with Soil Health Card data of Andhra Pradesh (India). [PDF]
Geoderma, 2022 Brus DJ +4 more
europepmc +1 more source
Bayesian Sample Size Determination for Case-Control Studies When Exposure May be Misclassified [PDF]
, 2013 L. Joseph, Patrick Bélisle
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
[Comparison of 7 methods for sample size determination based on confidence interval estimation for a single proportion]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Yu M, Shi X, Zou B, An S.
europepmc +1 more source
Sample Size Determination for Hierarchical Longitudinal Designs with Differential Attrition Rates [PDF]
, 2007 Anindya Roy +3 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Sample-size determination for the Bayesian t test and Welch's test using the approximate adjusted fractional Bayes factor. [PDF]
Behav Res Methods, 2021 Fu Q, Hoijtink H, Moerbeek M.
europepmc +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Efficient and flexible simulation-based sample size determination for clinical trials with multiple design parameters. [PDF]
Stat Methods Med Res, 2021 Wilson DT +4 more
europepmc +1 more source