Results 111 to 120 of about 17,778,637 (310)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

ryanboldi/Informed-Down-Sampled-Lexicase: Informed Down-Sampling Experimentation Code

open access: yes, 2023
<p>The state of code and supplementation for the paper</p> <p>"Informed Down-Sampled Lexicase Selection: Identifying productive training cases for efficient problem solving"</p ...
Thomas Helmuth   +7 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Average Consensus Tracking of Weight-Balanced Multi-Agent Systems via Sampled Data

open access: yesMathematics
This paper studies the average consensus tracking problem of first-order multi-agent systems under directed topologies. A control protocol is constructed based on the neighbors’ agent sampled information.
Baoyu Huo   +3 more
doaj   +1 more source

Data preprocessing and fitting algorithm based on marine data sampled by multiple underwater gliders

open access: yes, 2016
To our knowledge, this paper investigates the first application of the marine data sampled by multiple underwater gliders in the area of the South China Sea. We summarize six main characteristics of the sampled marine data.
Jia, Mingfei   +5 more
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The sample data for stMLnet

open access: yes, 2020
The input of stMLnet includes demo dataset and prior database. please refer to the following paper for more details: Cheng J, Yan L, Nie Q, Sun X*. Modeling and inference of spatial intercellular communications and multilayer signaling regulations using stMLnet. bioRxiv. 2022.   Files and datails: ex_databases: demo database `ex_databases`
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Sampled-data stabilization for Takagi-Sugeno fuzzy systems using membership function deviations

open access: yes, 2012
This paper is concerned with sampled-data stabilization for Takagi-Sugeno (T-S) fuzzy systems by using the property of membership function deviations.
Qing-Long Han (9801650)   +2 more
core  

Home - About - Disclaimer - Privacy