Results 101 to 110 of about 887,103 (337)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

One-Bit LFM Pulse Radar: Harmonic Analysis and Target Reconstruction

IEEE Access, 2019
One-bit radar, adopting one-bit analog-to-digital converters to perform signal sampling and quantization, is a promising technology for low-cost and resource-limited applications.
Benzhou Jin, Xiaofei Zhang, Bo Zhao, Gang Wu   +3 more
doaj   +1 more source

Signal and System Approximation from General Measurements

, 2014
In this paper we analyze the behavior of system approximation processes for stable linear time-invariant (LTI) systems and signals in the Paley-Wiener space PW_\pi^1.
A.J. Jerri, A.M. Olevskii, A.N. Kolmogorov, B.Y. Levin, C.E. Shannon, D. Hilbert, F. Schipp, H. Boche, H. Boche, H. Boche, J.R. Higgins, J.R. Higgins, J.R. Partington, L. Franks, M. Goldenbaum, N.J. Fine, P.J.S.G. Ferreira, P.J.S.G. Ferreira, P.J.S.G. Ferreira, P.L. Butzer, P.L. Butzer, P.L. Butzer, P.L. Butzer, P.L. Butzer, P.L. Butzer, P.L. Butzer, P.L. Butzer, R. Landauer, R. Landauer, R.L. Stens, R.M. Young, R.P. Boas, R.P. Feynman, S.J. Szarek, W. Sun, W. Sun, W. Sun, Z. Song   +37 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Dynamic stochastic blockmodels for time-evolving social networks

, 2014
Significant efforts have gone into the development of statistical models for analyzing data in the form of networks, such as social networks. Most existing work has focused on modeling static networks, which represent either a single time snapshot or an ...
Hero III, Alfred O., Xu, Kevin S.
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Hierarchical multi‐modal video summarization with dynamic sampling

IET Image Processing
Previous video summarization methods often neglected inter‐frame variations during the preprocessing stage. Sampling repeated frames can lead to information redundancy, while missing key frames can result in deviations in semantic comprehension and ...
Lingjian Yu, Xing Zhao, Liang Xie, Haoran Liang, Ronghua Liang   +4 more
doaj   +1 more source

Graph Variogram: A novel tool to measure spatial stationarity

, 2018
Irregularly sampling a spatially stationary random field does not yield a graph stationary signal in general. Based on this observation, we build a definition of graph stationarity based on intrinsic stationarity, a less restrictive definition of ...
Girault, Benjamin, Ortega, Antonio, Serrano, Alexander   +2 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Signal Processing for Novel Noise Radar Based on de-chirp and Delay Matching

Sensors
Modern radar technology requires high-quality signals and detection performance. However, traditional frequency-modulated continuous wave (FMCW) radar often has poor anti-jamming capabilities, and the high sampling rates associated with large time ...
Xinquan Cao, Shiyuan Zhang, Ke Tan, Jianchao Yang, Xingyu Lu, Zheng Dai, Hong Gu   +6 more
doaj   +1 more source