Results 171 to 180 of about 526,216 (298)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Real-Time Type 1 Diabetes Self-Management Decision-Making in Adolescents: Protocol for a Longitudinal Mixed Methods Study Using Text Messaging and Continuous Glucose Monitoring.

JMIR Res Protoc
DeJonckheere M, Chuisano SA, Lucien J, Amjad F, Duvvuri O, Khan H, Khan M, Mirza R, Ollivierre MJ, Guetterman T, Lin YK, Buis LR, Aikens JE, Richardson C, Lee JM.   +14 more
europepmc   +1 more source

Environmental Filtering Weakens with Trophic Level in Urban Coastal Ecosystems. [PDF]

Environ Sci Technol
Xu W, Pei YD, Li TMW, Bennett-Williams J, Sun R, Leung SKK, Ushio M, Wyatt ASJ, Yung CCM.   +8 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Breaking barriers: A study protocol on unveiling gender, racial and other intersectional dynamics in post-secondary institutions and identifying solutions for advancing primary care and public health research. [PDF]

PLoS One
Aggarwal M, Wong ST, Tricco AC, Turin TC, Lofters A, Agarwal G, Bhattacharyya B, Bourgeault IL.   +7 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Hybrid type 1 effectiveness-implementation studies: why and how to do them. [PDF]

Front Health Serv
Baloh J, Landes SJ, Smith JL, Curran GM.
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Education-Based Inequality in Edentulism and Functional Dentition Among Older Brazilian Adults: A Study Covering a Period of 20 Years. [PDF]

Int J Dent
Fonseca MLV, Gomes VE, Chamane LS, da Cruz CAG, Silva MLDN, Francisco ALG, Chalub LLFH, Ferreira RC.   +7 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source