Results 91 to 100 of about 7,951,181 (327)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Revista Jurídica AustralLa Ley 26659 sobre condiciones para la exploración y explotación de hidrocarburos en la plataforma continental argentina fue sancionada para proteger los recursos de petróleo y gas presentes en dicha zona y reafirmar la soberanía argentina sobre las ...
Carlos Sánchez Mas
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Boletín de literatura antigua cristiana
Estudios Eclesiásticos, 1975 El presente estudio realiza un recorrido por diferentes autores pertenecientes a la literatura antigua cristiana. De forma concreta, aborda los escritos y fuentes como san Ireneo, el Evangelium Petri, Lactancio, san Atanasio, san Eusebio de Cesarea, san ...
José A. de Aldama
doaj
PENERAPAN SAN REMO MANUAL PADA PENGIRIMAN (SATGAS MTF) TNI DALAM MISI UNIFIL
Arena Hukum, 2016 At the year of 2009 for the first time Indonesia took part by send a warships (KRI) for peacekeeping mission in UNIFIL (United Nations Mission Interim Forces in Lebanon).
Martha Latu Retno
doaj +1 more source
La liturgia del trabajo. «Levantado de la tierra, atraeré a todos hacia mí» (Jn 12, 32) en la experiencia de San Josemaría Escrivá de Balaguer. [PDF]
, 2006 Guillaume Derville
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Tạp chí Khoa học Đại học Cần Thơ, 2013 Vai trò và tiềm năng của thủy sản ở đồng bằng sông Cửu Long (ĐBSCL) đã được phân tích, đánh giá thông qua dữ liệu sẵn có. Kết quả thấy sản lượng khai thác cao nhất ở những tỉnh ven biển là Kiên Giang và Cà Mau, những tỉnh nội địa là An Giang và Đồng Tháp.
Trần Văn Việt
doaj
Méthode sans questions, questions sans méthods
Versants. Revista suiza de literaturas románicas, 2017 Dans tous ces cas, l’analyse littéraire joue le rôle d’un indispensable garde-fou épistémologique et on voit bien qu’elle est susceptible de s’appliquer à des corpus de discours qui ne sont pas proprement ‘littéraires’. Déléguer aux experts ‘non-littéraires’ la tâche que ces derniers doivent assumer, ce n’est pas seulement réduire la littérature à des ...
openaire +3 more sources