Results 101 to 110 of about 7,951,181 (327)
Moment polytopes for symplectic manifolds with monodromy
, 2005 A natural way of generalising Hamiltonian toric manifolds is to permit the presence of generic isolated singularities for the moment map. For a class of such ``almost-toric 4-manifolds'' which admits a Hamiltonian $S^1$-action we show that one can ...
Ngoc, San Vu
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Ciencias humanas, creencias y literatura
Austral ComunicaciónEn este trabajo se estudia, desde conceptos de la teoría de redes, la creación y articulación de las redes intelectuales católicas en la Europa de entreguerras.
Enrique Sánchez-Costa
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Erasto M. Villa: un diplomático argentino que prestigió su profesionalidad en Japón
Revista Política AustralEste artículo pretende destacar la profesionalidad y prestigio de los miembros del Servicio Exterior de la Nación de la República Argentina, especialmente la figura de quien fuera uno de sus miembros, el embajador Erasto M. Villa.
José Ramón Sanchis Muñoz
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Lexikos, 2010 Ferdie Weich. San Dictionary/San-woordeboek. San–Afrikaans–English/Eng-lish–San–Afrikaans/Afrikaans–San–English. First edition/eerste uitgawe. 2004, xi + 377 pp. ISBN 0 7978 2704 8. Johannesburg: Macmillan South Africa Publishers (Pty) Ltd. Price/Prys: R198.
openaire +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
eXPRESS Polymer Letters, 2010 Effect of solution-blended poly(styrene-co-acrylonitrile) (SAN) copolymer on crystallization of poly(vinylidene fluoride) (PVDF) was investigated by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and wide angle X ...
doaj +1 more source