Results 111 to 120 of about 7,676,917 (278)
Not a study of English! A corpus analysis of discourse features in spoken Burmese
Teanga: The Journal of the Irish Association for Applied Linguistics, 2019 This paper is part of a larger research project on the ‘Comparative analysis of discourse markers in Burmese and in English’, and the product of my attempt to identify so-called particles in Burmese in terms of their discourse functions.
San San Hnin Tun
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
"Cómo los superhéroes explican el mundo" de Mariano Turzi
Revista Política Austral, 2022 Alfonso Santiago
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KHẢO SÁT CÁC DẠNG SẢN PHẨM VÀ QUY TRÌNH CÔNG NGHỆ CHẾ BIẾN CÁC SẢN PHẨM TỪ CÁ LÓC TẠI TỈNH AN GIANG
Tạp chí Khoa học Đại học Cần Thơ, 2014 Đề tài nhằm khảo sát các dạng sản phẩm và quy trình công nghệ chế biến các sản phẩm từ cá lóc tại tỉnh An Giang với 3 nội dung (i) tình hình sản xuất và quy trình công nghệ chế biến sản phẩm; (ii) khảo sát các dạng sản phẩm; (ii) tình hình mua bán tại ...
Bùi Phương Đại +2 more
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Habitat parameters influencing the distribution of a geographically isolated flying squirrel
Conservation Science and PracticeThe San Bernardino flying squirrel (SBFS) is an isolated subspecies of Humboldt's flying squirrel, occurring in montane sky islands in the San Bernardino and San Jacinto Mountains in Southern California, USA.
Clark S. Winchell +6 more
doaj +1 more source