Results 21 to 30 of about 23,932 (249)

Effect of Implementing a Dashboard With or Without a Best Practice Alert on HLA‐B*58:01 Testing Rates Among Allopurinol Users at VA Medical Centers

Arthritis Care &Research, EarlyView.
Objective The American College of Rheumatology recommends HLA‐B*58:01 allele testing before the initiation of allopurinol, specifically among Asian and African American/Black patients, due to their increased risk for severe hypersensitivity reactions. However, testing rates remain low at many health care facilities.
Abimbola Fadairo‐Azinge, Gabriela Schmajuk, Sristi Sharma, Colleen P. Flanagan, Sara Faghihi‐Kashani, Ning Zhang, Mary A. Whooley   +6 more
wiley   +1 more source

The Association of Physical Function With Psychosocial Patient‐Reported Outcomes in People With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective To evaluate how modifiable psychosocial factors and fatigue relate to physical functioning in patients with systemic lupus erythematosus (SLE). Methods In this cross‐sectional study of two demographically distinct cohorts (Approaches to Positive, Patient‐Centered Experiences of Aging with Lupus [APPEAL] and California Lupus Epidemiology Study
Mrinalini Dey, Jessica Fitzpatrick, Maria Dall'Era, Charmayne Dunlop‐Thomas, Courtney Hoge, S. Sam Lim, Patricia P. Katz, Jinoos Yazdany, Laura C. Plantinga   +8 more
wiley   +1 more source

Exploring Healthcare Continuity in Pediatric‐Onset Multiple Sclerosis in the United States

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Little is known about shifting from pediatric to adult‐focused multiple sclerosis (MS) care. This study aims to explore transition of care and follow‐up in the US pediatric‐onset MS (POMS) population. Methods Surveys were distributed to 10 sites in the US Network of Pediatric MS Centers (US NPMSC) about transition‐of‐care practices ...
Aaron W. Abrams, Michael Waltz, Jonathan Race, T. Charles Casper, Claudia Gambrah‐Lyles, Kimberly O'Neill, Akash Virupakshaiah, Kristen S. Fisher, Melissa A. Wright, Kelsey E. Poisson, Eva‐Chava M. Bernfeld, Gregory Aaen, Leslie A. Benson, Tanuja Chitnis, Carla Francisco, Grace Y. Gombolay, Mark P. Gorman, Jennifer S. Graves, Lauren Krupp, Timothy E. Lotze, Soe Mar, Jayne Ness, Mary Rensel, Moses Rodriguez, Teri Schreiner, Nikita Shukla, Jan‐Mendelt Tillema, Bianca Weinstock‐Guttman, Yolanda Wheeler, Emmanuelle Waubant, John Rose, US Network of Pediatric MS Centers   +31 more
wiley   +1 more source

Population Pharmacokinetics and Exposure‐Response Analyses to Support Cofetuzumab Pelidotin (ABBV‐647) Dose Optimization in Non‐Small Cell Lung Cancer Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Cofetuzumab pelidotin (Cofe‐P) is an anti‐protein tyrosine kinase 7 (PTK7) antibody‐drug conjugate (ADC) being investigated for the treatment of adults with PTK7‐expressing, recurrent non‐small cell lung cancer (NSCLC). The first‐in‐human (FIH) trial demonstrated tolerability of dosages ≤ 2.8 mg/kg once every 3 weeks (Q3W) and ≤ 3.2 mg/kg Q2W ...
Carla Biesdorf, Melanie Rinas, Benjamin Engelhardt, Rabih Saab, Cen Guo, Cristiano Ferlini, Kevin J. Freise, Rajeev M. Menon, Akshanth R. Polepally   +8 more
wiley   +1 more source

Multimodal integration strategies for clinical application in oncology

Frontiers in Pharmacology
In clinical practice, a variety of techniques are employed to generate diverse data types for each cancer patient. These data types, spanning clinical, genomics, imaging, and other modalities, exhibit significant differences and possess distinct data ...
Baoyi Zhang, Zhuoya Wan, Yige Luo, Xi Zhao, Josue Samayoa, Weilong Zhao, Si Wu   +6 more
doaj   +1 more source

Seismic analysis and design of tunnels within fault ground: A review

Deep Underground Science and Engineering, EarlyView.
The research methods of seismic response of tunnels within fault ground, including field investigations, analytical solutions, physical experiments, and numerical simulations, and seismic countermeasures are discussed. The present study examines the shortcomings and limitations of the current research and design, and puts forward proposals for future ...
Xingda Wang, Yujing Jiang, Xuepeng Zhang, Yuyong Jiao, Ningbo Li, Xiao Wang, Bo Li   +6 more
wiley   +1 more source

Seismic Fragility of Gravity and Semi‐Gravity Retaining Walls and Its Impact on the Functionality Loss of Road Infrastructures

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Retaining walls are key geotechnical components of road infrastructure, whose seismic performance directly affects the resilience of transportation networks. Despite their importance, seismic fragility models for retaining walls available in the literature refer only to specific case studies.
Amendola C., Conti R., de Silva F.
wiley   +1 more source

Aftasten/Tantear: A sensorial, coalitional wayfinding among Muslim runners

Feminist Anthropology, EarlyView.
Abstract Muslim recreational runners in Muslim‐minority settings that take up running as their preferred form of leisure indicate that they feel they have to navigate a sense of exclusion when running outdoors. This article explores the process of exploration and sensing in public, represented by the Dutch verb aftasten, to investigate the way Muslim ...
Jasmijn Rana
wiley   +1 more source

A Novel Method for Comparing Building Height Hierarchies

Buildings
Understanding the hierarchical patterns of building heights is essential for sustainable urban development and planning. This study presents a novel approach for detecting and comparing building height hierarchies in four major bay areas: the San ...
Jun Xie, Bin Wu
doaj   +1 more source

In Vitro-In Vivo Correlation for the Degradation of Tetra-PEG Hydrogel Microspheres with Tunable β-Eliminative Crosslink Cleavage Rates

International Journal of Polymer Science, 2019
The degradation of Tetra-PEG hydrogels containing β-eliminative crosslinks has been studied in order to provide an in vitro-in vivo correlation for the use of these hydrogels in our chemically controlled drug delivery system.
Jeff Henise, Shaun D. Fontaine, Brian R. Hearn, Samuel J. Pfaff, Eric L. Schneider, Julia Malato, Donghui Wang, Byron Hann, Gary W. Ashley, Daniel V. Santi   +9 more
doaj   +1 more source