Results 31 to 40 of about 331,422 (279)

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, EarlyView.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source

Biological characteristics of the catch from the 1986-87 Pacific herring, Clupea harengus pallasi, roe fishery in California [PDF]

, 1987
In Tomales Bay, 4-, 5-, and 6-yr-old herring, Clupea harengus pallasi, composed 85% by number of the 1986-87 season's catch. In San Francisco Bay, 2-, 3-, and 4-yr-old herring composed 88% of the roundhaul catch, and 4-, 5-, and 6-yr-old herring composed
Spratt, Jerome D.
core  

Seismic analysis and design of tunnels within fault ground: A review

Deep Underground Science and Engineering, EarlyView.
The research methods of seismic response of tunnels within fault ground, including field investigations, analytical solutions, physical experiments, and numerical simulations, and seismic countermeasures are discussed. The present study examines the shortcomings and limitations of the current research and design, and puts forward proposals for future ...
Xingda Wang, Yujing Jiang, Xuepeng Zhang, Yuyong Jiao, Ningbo Li, Xiao Wang, Bo Li   +6 more
wiley   +1 more source

Biomass estimates of Pacific herring, Clupea pallasi, in California from the 1990-91 spawning-ground surveys [PDF]

, 1991
The spawning biomass of Pacific herring, Clupea pallasi, estimated from spawning-ground surveys in San Francisco Bay declined to 45,850 tons this season, following a peak of 71,000 tons in the 1989-90 season. This is the first major decline since the
Spratt, Jerome D.
core  

Consumer diversity drives stronger predation in tropical marine communities

Ecography, EarlyView.
Biotic interactions are predicted to be stronger in the tropics compared to higher latitudes, contributing to observed patterns of global biodiversity. While increased consumer diversity and more complex food webs are expected in tropical communities, the trophic dynamics underlying strong regional effects of predation are not well understood.
Michele F. Repetto, Gregory M. Ruiz, Mark E. Torchin, Mariana Bonfim, Amy L. Freestone   +4 more
wiley   +1 more source

In Vitro-In Vivo Correlation for the Degradation of Tetra-PEG Hydrogel Microspheres with Tunable β-Eliminative Crosslink Cleavage Rates

International Journal of Polymer Science, 2019
The degradation of Tetra-PEG hydrogels containing β-eliminative crosslinks has been studied in order to provide an in vitro-in vivo correlation for the use of these hydrogels in our chemically controlled drug delivery system.
Jeff Henise, Shaun D. Fontaine, Brian R. Hearn, Samuel J. Pfaff, Eric L. Schneider, Julia Malato, Donghui Wang, Byron Hann, Gary W. Ashley, Daniel V. Santi   +9 more
doaj   +1 more source

Resection of a giant mycotic left subclavian pseudoaneurysm

Journal of Vascular Surgery Cases and Innovative Techniques, 2022
Subclavian artery pseudoaneurysm due to intravenous drug use is a rare pathologic entity. A 6.6-cm left subclavian artery pseudoaneurysm immediately distal to the origin of the vertebral artery was discovered in a 39-year-old man with neck swelling ...
Sidney T. Le, MD, Genna Beattie, MD, Shahram Aarabi, MD, MPH   +2 more
doaj   +1 more source

Biomass estimates of Pacific herring, Clupea pallasi, in California from the 1991-92 spawning-ground surveys [PDF]

, 1992
The spawning biomass of Pacific herring, Clupea pallasi, estimated from spawning-ground surveys in San Francisco Bay declined to 41,000 tons this season.
Collier, Patrick, Moore, Thomas O., Spratt, Jerome D.   +2 more
core  

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley, Md. Monirul Islam, Dean J. Aguiar, Zoë Fuchs, Mackenzie Catron, Stephen Morairty, Ying Yuan, Radleigh Santos, Jingguo Hou, Annelies de Kater, George B. Thornton, Angelique Bordey   +11 more
wiley   +1 more source

A Novel Method for Comparing Building Height Hierarchies

Buildings
Understanding the hierarchical patterns of building heights is essential for sustainable urban development and planning. This study presents a novel approach for detecting and comparing building height hierarchies in four major bay areas: the San ...
Jun Xie, Bin Wu
doaj   +1 more source