Results 201 to 210 of about 1,323,764 (303)

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

open access: yesThe FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo   +16 more
wiley   +1 more source

Teleost‐specific ictacalcins exhibit similar structural organization, cation‐dependent activation, and transcriptional regulation as human S100 proteins

open access: yesThe FEBS Journal, EarlyView.
Calcium‐binding S100 proteins are important mediators of inflammation in humans. Distant members of this family have been recently discovered in teleost fish but their resemblance to human proteins has not been explored yet. This study demonstrates that zebrafish‐specific S100i1 and S100i2 (ictacalcins) possess identical structural organization and ...
Liz Hernández   +13 more
wiley   +1 more source

Environmental Drivers of Jumbo Squid During Fishery Collapse in the Gulf of California (2019–2024)

open access: yesFisheries Oceanography, EarlyView.
ABSTRACT The jumbo squid (Dosidicus gigas) is a cephalopod endemic to the eastern Pacific with significant ecological and economic importance. Its exploitation in the Gulf of California (GC) peaked in the 1990s, with catches exceeding 100,000 tons, but collapsed in 2009 and virtually disappeared by 2015, largely due to environmental changes and ...
Mario Vásquez‐Ortiz   +5 more
wiley   +1 more source

Effectiveness and tolerability of galcanezumab for migraine prevention in patients ≥65 years: A real‐life multicenter study

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary This study shows that galcanezumab is equally effective and well‐tolerated in patients aged 65 and older as in younger patients, with a higher proportion of excellent responders in older patients. Despite having more baseline headache days, older patients responded well to the treatment, with age being linked to better outcomes ...
Julia Peris‐Subiza   +27 more
wiley   +1 more source

Discordant Patch Test Reactions to 2‐Bromo‐2‐Nitro‐Propane‐1,3‐Diol (Bronopol): A Multicenter Study From REIDAC

open access: yes
Contact Dermatitis, EarlyView.
Tatiana Sanz Sánchez   +28 more
wiley   +1 more source

Culturally and Linguistically Diverse Informal Carer Experiences of Older Adult Care Transitions From Hospital to Home: A Scoping Review

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim To review the evidence on the experiences and perceptions of culturally and linguistically diverse informal carers supporting older adults during transitions from hospital to home, including their interactions with transitional care interventions. Design Scoping review guided by Arksey and O'Malley's framework.
Yaping Zhong   +10 more
wiley   +1 more source

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