Results 131 to 140 of about 2,924 (166)

Splicing defects in the ataxia-telangiectasia gene, ATM: underlying mutations and consequences. [PDF]

Am J Hum Genet, 1999
Teraoka SN, Telatar M, Becker-Catania S, Liang T, Onengüt S, Tolun A, Chessa L, Sanal O, Bernatowska E, Gatti RA, Concannon P.   +10 more
europepmc   +1 more source

Coherent Disaggregation and Uncertainty Quantification for Spatially Misaligned Data

Environmetrics, Volume 37, Issue 2, March 2026.
ABSTRACT Spatial misalignment arises when datasets are aggregated or collected at different spatial scales, leading to information loss. We develop a Bayesian disaggregation framework that links misaligned data to a continuous‐domain model through an iteratively linearised integration scheme implemented with the Integrated Nested Laplace Approximation (
Man Ho Suen, Mark Naylor, Finn Lindgren
wiley   +1 more source

Aneuploidy in the normal and diseased brain. [PDF]

Cell Mol Life Sci, 2006
Kingsbury MA, Yung YC, Peterson SE, Westra JW, Chun J.   +4 more
europepmc   +1 more source

Making Sense of Erotically Oppressive Lifeworlds: Dynamics of Testimonial Smothering and Testimonial Quieting

Journal of Social Philosophy, EarlyView.
Paul Giladi
wiley   +1 more source

Optimization of Pulsed Saturation Transfer MR Fingerprinting (ST MRF) Acquisition Using the Cramér–Rao Bound and Sequential Quadratic Programming

Magnetic Resonance in Medicine, Volume 95, Issue 3, Page 1778-1790, March 2026.
ABSTRACT Purpose To develop a method for optimizing pulsed saturation transfer MR fingerprinting (ST MRF) acquisition. Methods The Cramér–Rao bound (CRB) for variance assessment was employed on Bloch–McConnell‐based simulated signals, followed by a numerical sequential quadratic programming optimization and basin‐hopping avoidance of local minima ...
Nikita Vladimirov, Moritz Zaiss, Or Perlman   +2 more
wiley   +1 more source

Metformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol. [PDF]

Lancet Oncol
Gillessen S, Murphy L, James ND, Sachdeva A, El-Taji O, Abdel-Aty H, Adler AI, Amos C, Attard G, Varughese M, Gale J, Brown S, Srihari N, Birtle AJ, Brown M, Chan K, Chowdhury S, Cross W, Dearnaley DP, Din O, Dutey-Magni P, Gilbert DC, Gilson C, Gray S, Grist E, Hofmann U, Hudson AM, Jain Y, Jeyasangar G, Jones R, Kayani M, Langley RE, Malik Z, Mason MD, Matheson D, McAlpine C, Macnair A, Millman R, Murphy C, Padden-Modi M, Parikh O, Parker C, Rush H, Russell M, Srinivasan R, Sundar S, Tanguay JS, Turco F, Williams P, Sydes MR, Parmar MKB, Brown LC, Clarke NW, STAMPEDE investigators.   +53 more
europepmc   +1 more source

Influence of Basis Set Composition on Metabolite Quantification of 1H‐MRS at 3 T: Combining In Silico, In Vivo and In Vitro Evidence

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
We use synthetic (Aim 1), human brain (Aim 2) and phantom (Aim 3) data to assess how basis set choice affects Glu, tCr, tNAA and tCho quantification, focusing on the bias–variance trade‐off under varying SNR conditions. Including GABA, GSH, NAAG and glucose improved Glu estimates, reducing bias and variance below 10%.
Polina Emeliyanova, Laura M. Parkes, Caroline Lea‐Carnall, Stephen R. Williams   +3 more
wiley   +1 more source

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial. [PDF]

Lancet
Parker CC, Clarke NW, Cook AD, Kynaston H, Catton CN, Cross WR, Petersen PM, Persad RA, Saad F, Bower LC, Logue J, Payne H, Forcat S, Goldstein C, Murphy C, Anderson J, Barkati M, Bottomley DM, Branagan J, Choudhury A, Chung PWM, Cogley L, Goh CL, Hoskin P, Khoo V, Malone SC, Masters L, Morris SL, Nabid A, Ong AD, Raman R, Tarver KL, Tree AC, Worlding J, Wylie JP, Zarkar AM, Parulekar WR, Parmar MKB, Sydes MR, RADICALS investigators.   +39 more
europepmc   +1 more source

How to Be Hopeful About Climate Change

American Anthropologist, Volume 128, Issue 1, Page 148-158, March 2026.
ABSTRACT Why do people in climate‐vulnerable regions of Kenya and Namibia express more hope for the future than many in Germany, despite facing greater environmental threats? Drawing on ethnographic research and the philosophy of Gabriel Marcel, we make two arguments.
Julian Sommerschuh, Michael Schnegg
wiley   +1 more source

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial. [PDF]

Lancet
Parker CC, Kynaston H, Cook AD, Clarke NW, Catton CN, Cross WR, Petersen PM, Persad RA, Pugh CA, Saad F, Logue J, Payne H, Bower LC, Brawley C, Rauchenberger M, Barkati M, Bottomley DM, Brasso K, Chung HT, Chung PWM, Conroy R, Falconer A, Ford V, Goh CL, Heath CM, James ND, Kim-Sing C, Kodavatiganti R, Malone SC, Morris SL, Nabid A, Ong AD, Raman R, Rodda S, Wells P, Worlding J, Parulekar WR, Parmar MKB, Sydes MR, RADICALS investigators.   +39 more
europepmc   +1 more source