Results 91 to 100 of about 29,738 (266)

Commodity trade in the Asia-Pacific: Assessing the short- and long-term impact of sanctions

open access: yesJournal of New Economy
Russia’s commodities-based export influences the development of its economy. The European sanctions stimulated the need to redirect Russia’s commodities to countries in other regions, including the Asia-Pacific. APAC accounted for half of the world trade
Dmitrii A. Izotov
doaj   +1 more source

Sanctioning the sanctioned : A postcolonial perspective on the sanctions paradox

open access: yes, 2020
The aim of this is to develop a theoretical framework for addressing the usage and effects of economic sanctions, through a postcolonial perspective on the human rights discourse, by examining how economic sanctions can be legitimized even though proven to be ineffective and harmful to civilians.
openaire   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Regime Type, Issue Type and Economic Sanctions: The Role of Domestic Players

open access: yesEconomies, 2019
This analysis highlights the significant role that domestic actors play in determining the outcomes of economic sanctions. It models the behavior of the main opposition party during an economic sanction episode, and introduces two commonly used variables
Mehmet Onder
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Dark Side of the Moon: Sanctions, Security, and Nuclear Decision-Making in Iran

open access: yesBTTN Journal
Although the Treaty on the Non-Proliferation of Nuclear Weapons does not explicitly mention it, the idea that sanctions can be used as a tool to prevent the spread of nuclear weapons is not new. The earliest mention of it appears in the 1946 Baruch Plan,
Rizwan  Zeb
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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