Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
From violation to stigma: a literature review of athletes' lived experiences following anti-doping sanctions. [PDF]
Front Sports Act LivingLockett I +5 more
europepmc +1 more source
REPAYMENT INCENTIVES AND THE DISTRIBUTION OF GAINS FROM GROUP LENDING [PDF]
Group loans with joint liability have been a distinguishing feature of many micronance programs. While such lending has benetted millions of borrowers, major lending insti- tutions have acknowledged their limited impact among the very poor and have ...
Jean-Marie Baland +2 more
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Attitudes and behaviours on driving under the influence of drugs: a multigroup analysis of non-drug users and people who use methamphetamine. [PDF]
Harm Reduct JMackay A +4 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
How peer mechanism impacts loan repayment in a Self-help group?: An empirical study in India. [PDF]
PLoS OneMalhotra N.
europepmc +1 more source
Risk Sharing and Moral Hazard with a Stability Pact [PDF]
We show how a stability pact based on deficit sanctions eliminates the exacerbation of debt accumulation that may arise from monetary unification. Moreover, by making sanctions contingent upon the economic situation of countries, the stability pact ...
Henrik Jensen, Roel Beetsma
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Empowering Resilience through Medical Tourism: Addressing Economic Challenges in Healthcare Systems of Sanction-Affected Nations. [PDF]
Iran J Public HealthRahmanpour MH +3 more
europepmc +1 more source