Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Juvenile sanctions for young adult offenders in the Netherlands: an opportunity for rehabilitation? [PDF]
Prop LJC +4 more
europepmc +1 more source
Far-Reaching Consequences of U.S. Financial Sanctions. The Dollar Shortage and the "Triffin Moment"
Miriam L. Campanella
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Designing a national framework for preventing fraud in Iran's health system: a sequential mixed-methods study using qualitative analysis and Delphi consensus. [PDF]
Vafaee Najar A, Hooshmand E.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Effects of economic sanctions on cancer care for patients in Iran: a qualitative study. [PDF]
Nazari M +7 more
europepmc +1 more source
Implementation of Criminal Sanctions Against Perpetrators of Corruption Crimes Committed by the Head of Pekon Pagar Village in Pesisir Barat (Study Decision Number: 11/Pid.Sus-Tpk/2023/PN.Tjk) [PDF]
Zulva Ica
openalex +1 more source

