Results 61 to 70 of about 9,029 (214)

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

The sandfly vectors and epidemiology of cutaneous leishmaniasis in the Landazury Focus, Colombia. [PDF]

This thesis describes a comprehensive cohort study of cutaneous leishmaniasis (CL) in a population of 2,704 followed over a period of 19 months, in the Opon focus, Landazury, Santander, Colombia.
Munoz-Mantilla, Gerardo
core   +1 more source

First description of Leishmania (Viannia) infection in Evandromyia saulensis, Pressatia sp. and Trichophoromyia auraensis (Psychodidae: Phlebotominae) in a transmission area of cutaneous leishmaniasis in Acre state, Amazon Basin, Brazil

Memorias do Instituto Oswaldo Cruz
Studies on the sandfly fauna to evaluate natural infection indexes are still limited in the Brazilian Amazon, a region with an increasing incidence of cutaneous leishmaniasis.
Thais de Araujo-Pereira, Daniela de Pita-Pereira, Mariana Côrtes Boité, Myllena Melo, Taiana Amancio da Costa-Rego, Andressa Alencastre Fuzari, Reginaldo Peçanha Brazil, Constança Britto   +7 more
doaj   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, Volume 15, Issue 30, 14 August 2026.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
Camila S. de Freitas, Eduardo Oliveira S. da Silva, Daniela C. Tristão, Guilherme M. Antar, Daniela P. Lage, Dóris M. Abrão, Luciana M. Ribeiro Antinarelli, Elaine S. Coimbra, João Henrique G. Lago, Eduardo A. F. Coelho   +9 more
wiley   +1 more source

Cocirculation of 2 Genotypes of Toscana Virus, Southeastern France

Emerging Infectious Diseases, 2007
Toscana virus (TOSV), an arthropodborne phlebovirus transmitted by sandflies, can cause febrile illness and meningitis. The vector of TOSV in France was unknown. We detected TOSV RNA in 2 (female Phlebotomus perniciosus) of 61 pools of sandflies captured
Remi N. Charrel, Arezki Izri, Sarah Temmam, Pascal Delaunay, Isabelle Toga, Henri Dumon, Pierre Marty, Xavier de Lamballerie, Philippe Parola   +8 more
doaj   +1 more source

Sandfly surveillance and investigation of Leishmania spp. DNA in sandflies in Kosovo

Medical and Veterinary Entomology, 2020
Abstract In the past decade, leishmaniasis seems to be re‐emerging in Balkan countries. There are serious implications that Kosovo is a visceral leishmaniasis endemic region with autochthonous transmission; nevertheless, surveillance of vectors, reservoirs or the disease is not yet established.
Vaselek, S., Oguz, G., Ayhan, N., Ozbel, Y., Kadriaj, P., Ćupina, A. I., Velo, E., Muja, N., Baymak, D., Alishani, M., Toz, S., Nalcaci, M., Sherifi, K., Charrel, R., Alten, B., Petrić, D.   +15 more
openaire   +4 more sources

Climate and Edaphic Factors Partly Explain Leaf Litterfall Rates of Species From Tropical Semi‐Deciduous Ecosystems

Ecology and Evolution, Volume 16, Issue 8, August 2026.
Semi‐deciduous ecosystems have short leaf‐shedding periods, making carbon cycling and litterfall patterns difficult to study. This study compiled data from 31 global sites and used regression models to examine how climate and soil factors influence leaf litterfall rates.
Ashehad A. Ali, Anuj T. Magar
wiley   +1 more source

Seroconversion for infectious pathogens among UK military personnel deployed to Afghanistan, 2008-2011. [PDF]

, 2014
Military personnel are at high risk of contracting vector-borne and zoonotic infections, particularly during overseas deployments, when they may be exposed to endemic or emerging infections not prevalent in their native countries.
Andrew Bosworth, Hewson, Roger, Edmund N.C. Newman, Tim Brooks, Wright, Deborah, Hannah Bridge, Newman, Edmund NC, Andrew Green, Roger Hewson, Lisa Jameson, Ross, David, Green, Andrew, Osborne, Jane, Jenny Hayward-Karlsson, Mark S. Bailey, Bailey, Mark S, Brooks, Tim, Johnstone, Penelope, Deborah Wright, Penelope Johnstone, Rebecca Hatch, Jameson, Lisa, Bosworth, Andrew, Bridge, Hannah, Hatch, Rebecca, Hayward-Karlsson, Jenny, Jane Osborne, David Ross   +27 more
core   +1 more source

A systematic review and meta-analysis of the prevalence of Leishmania infantum in sandflies in Iran

Asian Pacific Journal of Tropical Medicine
Objective: To determine the overall and pooled prevalence of Leishmania (L.) infantum in sandfly vectors in Iran. Methods: The present research conducted a systematic review and meta-analysis and searched regional databases such as PubMed, Scopus, Web of
Sara Rahimi, Homa Arshadi, Hamid Reza Shoraka, Aioub Sofizadeh, Arman Latifi   +4 more
doaj   +1 more source