Results 41 to 50 of about 3,649,371 (299)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Experimental investigation on mechanical behavior of sandwich structures using Digital Image Correlation (DIC)

Fracture and Structural Integrity
The aim of this work is to investigate the mechanical behavior of sandwich structures when subjected to edgewise and flatwise compression loadings, using 2D Digital Image Correlation (DIC).
Amina Masmoudi, Abdelhak Khechai, Ahmed Bouaziz Laboratory of Research in Civil Engineering, Mohamed Khider University of Biskra, Algeria., Guerira Belhi Mechanical Engineering Laboratory, University of Biskra, Algeria., Afaf Zeroual, Yassine Adimi   +5 more
doaj   +1 more source

Experimental validation of efficient impact simulation methodologies of sandwich structures [PDF]

, 2007
Aircraft design calls for weight efficient shell constructions. Composite sandwich structures satisfy this demand by the combination of two thin, stiff face sheets and an intermediate lightweight core.
Kärger, Luise, Baaran, Jens, Teßmer, Jan   +2 more
core  

Modeling impact on aluminium sandwich including velocity effects in honeycomb core [PDF]

, 2013
A numerical model has been developed on metallic sandwich structures as an armor for aeronautical applications. Several combinations of AA5086-H111 aluminium skins and aluminium honeycomb core have been studied, considering medium-velocity and highenergy
Alvarado, Raquel, Bouvet, Christophe, Rivallant, Samuel, Kolopp, Amélie   +3 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Multiscale Approach for the Design of Composite Sandwich Elements [PDF]

, 2010
In the present work, composite sandwich components, that perfectly match the challenging demands of lightweight and more customized structures, have been characterized and designed as a roof panels of a railway vehicle.
Zinno, Alberto
core   +1 more source

Structural behaviour of folded timber sandwich structures

Thin-Walled Structures, 2021
This paper aims to characterise the mechanical behaviour of folded timber sandwich structures developed using integral rotational press-fit (RPF) joints. Six folded arches are tested to failure, under three load cases designed to induce different sagging and hogging conditions at internal joints.
Yousef Alqaryouti, Dilum Fernando, Joseph M. Gattas   +2 more
openaire   +3 more sources

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Enhanced the impact resistance by gradient face-sheet design of a sandwich structure

Journal of Materials Research and Technology, 2023
Sandwich structure has been designed to reduce the impact damage of the stress waves. However, the existing work focuses on the optimization of sandwich cores while the face-sheet structure is seldom improved.
Jing Wei, Guoqiang Luo, Ao Liu, Qinqin Wei, Zhilin Xia, Ruizhi Zhang, Qiang Shen   +6 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source