Results 21 to 30 of about 798,007 (248)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Le droit à la santé: des objectifs de l’OMS à ceux ans du Millenium

Arbor: Ciencia, Pensamiento y Cultura, 2010
El derecho a la salud viene proclamado por Las Naciones Unidas en la Declaración de los Derechos del Hombre de 1948. En 1981 la ONU erige ese derecho en un objetivo del nuevo Milenio. En este texto muestro que los objetivos del Milenio, por generosos que
Caroline Guibet Lafaye
doaj   +1 more source

Usage des pesticides et impacts sur la santé des applicateurs en zone cotonnière du Mali

Cahiers Agricultures, 2022
Au Mali, le répertoire des pesticides utilisés en agriculture est vaste et les études de leurs impacts sur la santé sont rares. Des travaux de recherche sur les impacts des pesticides utilisés en productions cotonnière, céréalière et maraîchère sur la ...
Le Bars Marjorie, Sissako Aliou, de Montgolfier Alban, Sidibe Yaya, Diarra Abdourahamane, Sagara Augustin, Koita Ousmane   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Démocratie en santé et santé bucco-dentaire

International audienceThe Conférence nationale de santé (CNS) (French National Health Conference) is a consultative health democracy body that reportsto the Minister of Health.
Ghadi, Sidi-Mohammed, Baudot, Patrick, Marquillier, Thomas, Brun, Christian, Tubert-Jeannin, Stéphanie, Walger, Roland, Rusch, Emmanuel, Denis, Frédéric, Clément, Céline   +8 more
core   +5 more sources

Le boisement et la conservation de la forêt de Rambouillet du XVIII^e siècle à nos jours

Revue Forestière Française
La forêt tient un rôle central dans le paradigme de la conservation de la nature né en Europe entre le XVIIe et le XIXe siècle. Le boisement y est considéré comme un bon état de santé de la sylve, espace peuplé d’arbres à vocation de production.
Raphaël Devred
doaj   +1 more source

Collaborations, évitements et conflits entre disciplines autour d’un terrain partagé [PDF]

Natures Sciences Sociétés, 2016
Cet article interroge les collaborations, les conflits et les évitements qui se nouent entre disciplines autour d’un terrain d’étude partagé. À l’aide de la notion d’espace-frontière, j’analyserai l’exemple de la forêt périparisienne ...
Massart Clémence
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Les jeunes enfants à Bruxelles : d’une logique institutionnelle à une vision systémique

Brussels Studies, 2015
In the Belgian federal system, matters related to persons are under the remit of the Community and not of the Region. But although matters such as education and culture are managed in a French- or Dutch-language framework, they are major challenges for ...
Perrine Humblet, Gaëlle Amerijckx, Stéphane Aujean, Murielle Deguerry, Michel Vandenbroeck, Benjamin Wayens   +5 more
doaj   +1 more source