Results 31 to 40 of about 1,213,624 (251)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Le boisement et la conservation de la forêt de Rambouillet du XVIII^e siècle à nos jours

Revue Forestière Française
La forêt tient un rôle central dans le paradigme de la conservation de la nature né en Europe entre le XVIIe et le XIXe siècle. Le boisement y est considéré comme un bon état de santé de la sylve, espace peuplé d’arbres à vocation de production.
Raphaël Devred
doaj   +1 more source

Le droit à la santé: des objectifs de l’OMS à ceux ans du Millenium

Arbor: Ciencia, Pensamiento y Cultura, 2010
El derecho a la salud viene proclamado por Las Naciones Unidas en la Declaración de los Derechos del Hombre de 1948. En 1981 la ONU erige ese derecho en un objetivo del nuevo Milenio. En este texto muestro que los objetivos del Milenio, por generosos que
Caroline Guibet Lafaye
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Les jeunes enfants à Bruxelles : d’une logique institutionnelle à une vision systémique

Brussels Studies, 2015
In the Belgian federal system, matters related to persons are under the remit of the Community and not of the Region. But although matters such as education and culture are managed in a French- or Dutch-language framework, they are major challenges for ...
Perrine Humblet, Gaëlle Amerijckx, Stéphane Aujean, Murielle Deguerry, Michel Vandenbroeck, Benjamin Wayens   +5 more
doaj   +1 more source

Usage des pesticides et impacts sur la santé des applicateurs en zone cotonnière du Mali

Cahiers Agricultures, 2022
Au Mali, le répertoire des pesticides utilisés en agriculture est vaste et les études de leurs impacts sur la santé sont rares. Des travaux de recherche sur les impacts des pesticides utilisés en productions cotonnière, céréalière et maraîchère sur la ...
Le Bars Marjorie, Sissako Aliou, de Montgolfier Alban, Sidibe Yaya, Diarra Abdourahamane, Sagara Augustin, Koita Ousmane   +6 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Collaborations, évitements et conflits entre disciplines autour d’un terrain partagé [PDF]

Natures Sciences Sociétés, 2016
Cet article interroge les collaborations, les conflits et les évitements qui se nouent entre disciplines autour d’un terrain d’étude partagé. À l’aide de la notion d’espace-frontière, j’analyserai l’exemple de la forêt périparisienne ...
Massart Clémence
doaj   +1 more source