Results 21 to 30 of about 468,211 (255)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Bolivian Studies Journal, 2014 Carlos Hugo Molina Saucedo. Andrés Ibáñez, un caudillo para el siglo XXI. La Comuna de Santa Cruz de la Sierra de 1876Andrey Schelchkov. Andrés Ibáñez y la Revolución de la Igualdad en Santa Cruz: primer ensayo de federalismo en Bolivia, 1876 ...
Clayton Mendonça Cunha Filho
doaj +1 more source
Publicación Electrónica de la Asociación Paleontológica Argentina, 2020 In this contribution, the first anuran fossils from classical Santacrucian localities of the Río Santa Cruz are described. According to proportions and features recognized in the few skull elements recorded, the remains are assigned to the southern gondwanan Calyptocephalella cf. canqueli.
openaire +4 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Dinámicas sociales en la década del 90: trayectoria laboral petrolera en el norte de Santa Cruz
Informes Científicos y Técnicos (Universidad Nacional de la Patagonia Austral), 2020 Santa Cruz, es una provincia caracterizada por el fuerte impacto laboral de las empresas petroleras en la década del 90. Esto permitió el crecimiento de la población por medio de la migración de mano de obra proveniente de otras provincias. Pico Truncado
Pamela Soledad Leopardo, Dina Rozas
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Publicación Electrónica de la Asociación Paleontológica Argentina, 2019 The Santa Cruz Formation (Early–Middle Miocene) is one of the most widespread sedimentary units of the Argentine Patagonia. This unit contains an abundant and taxonomically diverse fossil vertebrate fauna, especially in mammals. Thus, the paleoecological
Leandro Martín Pérez +3 more
doaj
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source