Results 31 to 40 of about 2,562,050 (291)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Variedades de cerezas utilizadas en Santa Cruz
, 2003 Las nuevas técnicas de manejo apuntan a obtener un máximo provecho de las plantas, como así tambien sacar el maximo rendimiento por unidad de superficie.
Guerendiain, Federico +1 more
core +1 more source
Publicación Electrónica de la Asociación Paleontológica Argentina, 2019 The Santa Cruz Formation (Early–Middle Miocene) is one of the most widespread sedimentary units of the Argentine Patagonia. This unit contains an abundant and taxonomically diverse fossil vertebrate fauna, especially in mammals. Thus, the paleoecological
Leandro Martín Pérez +3 more
doaj
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Publicación Electrónica de la Asociación Paleontológica Argentina, 2019 Four specimens of primates were collected from the Santa Cruz Formation (Early–Middle Miocene) during expeditions undertaken by the Museo de la Plata, Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”, and Duke University in 2013, 2014, and ...
Richard Frederick Kay +1 more
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Producción de frutillas en Santa Cruz
, 2003 De acuerdo a ensayos realizados en Río Gallegos existen dos variedades de frutilla que tienen un comportamiento adecuado a las condiciones climáticas de la región.
Mora, Julio Cesar
core +1 more source
Publicación Electrónica de la Asociación Paleontológica Argentina, 2019 The Thematic Volume “Early-Middle Miocene Paleontology in the Río Santa Cruz, Southern Patagonia, Argentina. 130 years since Ameghino, 1887” deals with the geology, chronology and the fossils of the Santa Cruz Formation in the Río Santa Cruz recovered in
Juan C. Fernicola +3 more
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