Results 51 to 60 of about 482,619 (260)
El registro biológico humano de la costa meridional de Santa Cruz
Revista Argentina de Antropología Biológica, 2010 RESUMEN La costa patagónica constituye un sector de riesgo para el registro arqueológico, asociado a factores naturales y antrópicos. Al mismo tiempo, la conservación de las colecciones bioarqueológicas, destacándose la pérdida de restos óseos e ...
Jorge A. Suby +2 more
doaj +2 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Publicación Electrónica de la Asociación Paleontológica Argentina, 2019 Litopterna from fossiliferous exposures of the Santa Cruz Formation (Early–Middle Miocene) along the Río Santa Cruz, Patagonia Argentina, are analyzed and described.
Gabriela Ines Schmidt +3 more
doaj
Evaluación de la Avifauna Para Uso Ecoturístico en Humedales del Sur de Santa Cruz
Informes Científicos y Técnicos (Universidad Nacional de la Patagonia Austral), 2017 Este estudio comprende una valoración cuali-cuantitativa de las especies de aves asociadas ecológicamente a humedales del sur de la provincia de Santa Cruz, Argentina.
Ariel Almendras +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
O arquivo pessoal de José Petronilo de Santa Cruz: o livreiro-editor da Livraria Duas Cidades
Revista do Instituto de Estudos Brasileiros, 2020 RESUMO Este artigo investiga o arquivo pessoal de José Petronilo de Santa Cruz e abarca aspectos (auto)biográficos e da cultura escrita relacionada à Livraria Duas Cidades, fundada e dirigida por Santa Cruz na cidade de São Paulo.
Hugo Quinta, Wilton Carlos Lima da Silva
doaj +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source