Results 71 to 80 of about 482,619 (260)

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Fabio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

El registro biológico humano de la costa meridional de Santa Cruz

Revista Argentina de Antropología Biológica, 2009
La costa patagónica constituye un sector de riesgo para el registro arqueológico, asociado a factores naturales y antrópicos. Al mismo tiempo, la conservación de las colecciones bioarqueológicas, destacándose la pérdida de restos óseos e información ...
Suby, Jorge A., Guichón, Ricardo Aníbal, Zangrando, Francisco Atilio   +2 more
doaj  

HTLV-1/2 prevalence in two Amazonian communities

Journal of Virus Eradication, 2018
Introduction: The human T-cell lymphotropic virus type 1 (HTLV-1) is aetiologically linked to myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukaemia (ATL) besides other less incident pathologies, while the type 2 has not been ...
Elida C.G. Mata, Roberto M. Bezerra, Aldo A. Proietti Júnior, Luana K.S. Pamplona, Lilian O. Gomes, Valmir C. Corrêa, Jordan S.R. Caluff, Geanny S. Borges, J. Casseb, L.I.B. Kanzaki   +9 more
doaj   +1 more source

Highlights of the 'I Congress ecancer Choosing Wisely' March 30 and 31, 2022 Santa Cruz, Bolivia. [PDF]

Ecancermedicalscience, 2022
Limón R, Reynolds L, Rocha E, Richter L, Gianella M, de Guzman ON, Mejia G, Nina J, Rojas W, Avilés L, Maldonado I, Pacheco C, Martín C, Cervantes MG, Bakal F, Cazap E.   +15 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Estratigrafía en el oriente de la Bahía de la Lancha. Lago San Martín, Santa Cruz, Argentina

Revista del Museo de La Plata
Eu el área de la Bahía de la Lancha afloran las siguientes nnidades litoestratigr:,ficas : 1) Formación Bahía de la Lancha: Psammitas y pelitas marinas de espesor desconocido, del Devónico superior-Carbónico inferior; 2) Conglomerado AJTo~'() de la Mina (
Alberto C. Riccardi
doaj  

EVALUATION OF LANDFILL BIOGAS POTENTIAL IN BOLIVIA TO PRODUCE ELECTRICITY

Investigación & Desarrollo, 2017
The potential to produce electricity using landfill biogas in Bolivia was studied in this article. There important locations (Santa Cruz, La Paz and Cochabamba) and their solid waste disposal characteristics were considered.
Juan Pablo Vargas Bautista, Jorge Calvimontes   +1 more
doaj