Results 61 to 70 of about 122,915 (293)

Development and validation of BCG vaccine‐induced novel granulomatous liver injury preclinical animal model

Animal Models and Experimental Medicine, EarlyView.
The study successfully developed and validated a granulomatous liver injury model using a high‐dose BCG vaccine, simulating hepatic tuberculosis and autoimmune granulomatous liver diseases. Pharmacokinetic analysis examined the metabolic behavior of first‐line antitubercular drugs (isoniazid and rifampicin) and their main metabolites under conditions ...
Swati Sharma, Abhishek Moudgil, Jyoti Grewal, Pankaj Khatri, Vishal Sharma, Madhumita Premkumar, Amanjit Bal, Dibyajyoti Banerjee, Amol N. Patil   +8 more
wiley   +1 more source

Cluster Activation Mapping with Applications to Medical Imaging [PDF]

arXiv, 2020
An open question in deep clustering is how to understand what in the image is creating the cluster assignments. This visual understanding is essential to be able to trust the results of an inherently complex algorithm like deep learning, especially when the derived cluster assignments may be used to inform decision-making or create new disease sub ...
arxiv  

In Which Patients with Sarcoidosis Is FDG PET/CT Indicated?

Journal of Clinical Medicine, 2020
Sarcoidosis is a granulomatous disease of which the etiology remains unknown. The diverse clinical manifestations may challenge clinicians, particularly when conventional markers are inconclusive.
R. Keijsers, J. Grutters
semanticscholar   +1 more source

Active chronic sarcoidosis is characterized by increased transitional blood B cells, increased IL-10-producing regulatory B cells and high BAFF levels.

PLoS ONE, 2012
BackgroundSarcoidosis is a multisystemic disease of unknown etiology characterized by a disproportionate Th1 granulomatous immune response in the organs involved.
Anne Saussine, Abdellatif Tazi, Séverine Feuillet, Michel Rybojad, Caroline Juillard, Anne Bergeron, Valérie Dessirier, Fatiha Bouhidel, Anne Janin, Armand Bensussan, Martine Bagot, Jean-David Bouaziz   +11 more
doaj   +1 more source

Phenotypes of organ involvement in sarcoidosis

European Respiratory Journal, 2018
Sarcoidosis is a highly variable, systemic granulomatous disease of hitherto unknown aetiology. The GenPhenReSa (Genotype–Phenotype Relationship in Sarcoidosis) project represents a European multicentre study to investigate the influence of genotype on ...
J. Schupp, S. Freitag-Wolf, E. Bargagli, V. Mihailović-Vučinić, P. Rottoli, Aleksandar Grubanovic, A. Müller, A. Jochens, L. Tittmann, J. Schnerch, C. Olivieri, A. Fischer, D. Jovanovic, S. Filipović, Jelica Videnovic-Ivanovic, P. Bresser, R. Jonkers, K. O'Reilly, L. Ho, K. Gaede, P. Zabel, A. Dubaniewicz, B. Marshall, R. Kieszko, J. Milanowski, A. Günther, Anette Weihrich, M. Petrek, V. Kolek, M. Keane, S. O'Beirne, S. Donnelly, S. Haraldsdóttir, K. Jorundsdottir, U. Costabel, F. Bonella, B. Wallaert, C. Grah, T. Peroš-Golubičić, M. Luisetti, Zamir Kadija, S. Pabst, C. Grohé, J. Strausz, M. Vašáková, M. Sterclova, A. Millar, J. Homolka, A. Slováková, Y. Kendrick, A. Crawshaw, W. Wuyts, L. Spencer, M. Pfeifer, D. Valeyre, V. Poletti, H. Wirtz, A. Prasse, S. Schreiber, M. Krawczak, J. Müller‐Quernheim   +60 more
semanticscholar   +1 more source

Differentiating reactive and neoplastic gamma‐delta (γδ) T‐cell expansions in the peripheral blood and bone marrow

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract The clinical and immunophenotypic attributes of reactive γδ T‐cell expansions are less well characterized than their malignant counterparts, which can pose diagnostic challenges. This study aims to investigate the characteristics and long‐term clinical outcomes of reactive γδ T‐cell expansions.
Hamza Tariq, Zubair Ilyas, Lucy Fu, Yijie Liu, Qing Ching Chen, Kristy Wolniak, Yi‐Hua Chen   +6 more
wiley   +1 more source

Autoimmune pulmonary alveolar proteinosis in a patient with sarcoidosis

Clinical Case Reports, 2019
Key Clinical Message Steroids used to treat sarcoidosis may induce aPAP. The cooccurrence of sarcoidosis and autoimmune pulmonary alveolar proteinosis (aPAP) is rare.
Yuko Tanaka, Toshihiro Shirai, Kazuhiro Asada, Aya Muramatsu, Mineo Katsumata, Takafumi Suda   +5 more
doaj   +1 more source

Long‐term outcomes of electrical storm patients listed for urgent heart transplantation but not transplanted acutely

ESC Heart Failure, EarlyView.
Abstract Aims Refractory electrical storm (ES) is a life‐threatening condition in which heart transplantation (HTx) can be proposed. Nevertheless, the shortage of donors and subsequent outcomes question its place as a rescue strategy. We aim to describe the prognosis of ES patients listed for HTx but not transplanted.
Miloud Cherbi, Philippe Maury, Léa Benabou, Maxime Faure, Matteo Pozzi, Laurent Sebbag, Estelle Gandjbakhch, Karim Benali, Pierre Groussin, Redwane Rakza, Raphael P. Martins, Clément Delmas   +11 more
wiley   +1 more source

Sarcoidosis and breast cancer: A retrospective case series

Respiratory Medicine Case Reports, 2020
Background: Sarcoidosis and breast cancer co-incidence is reported in the literature in the form of case reports. Aim: To describe our experience from a single large sarcoidosis clinic.
Ilias C. Papanikolaou, Hidenobu Shigemitsu   +1 more
doaj  

TREM-1 and TREM-2 Expression on CD14+ Cells in Bronchoalveolar Lavage Fluid in Pulmonary Sarcoidosis and Hypersensitivity Pneumonitis in the Context of T Cell Immune Response

Mediators of Inflammation, 2020
Background. Sarcoidosis and hypersensitivity pneumonitis (HP) are immunologically mediated processes caused by hypersensitivity reaction accompanied by similar features including lymphocytic alveolitis and granuloma formation. Recent studies describe the
M. Suchankova, J. Urban, M. Ganovska, E. Tibenska, K. Szaboova, E. Tedlova, F. Sandor, I. Majer, M. Bobovcak, I. Jonner, B. Konig, M. Bucova   +11 more
doaj   +1 more source