Results 1 to 10 of about 698,336 (388)

Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

BMC Cancer, 2019
Background Liposarcoma (LPS) is a tumor derived from adipose tissue, and has the highest incidence among soft tissue sarcomas. Dedifferentiated liposarcoma (DDLPS) is a malignant tumor with poor prognosis.
Eun Byeol Jo, Young Sang Lee, Hyunjoo Lee, Jae Berm Park, Hyojun Park, Yoon-La Choi, Doopyo Hong, Sung Joo Kim   +7 more
doaj   +1 more source

Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma

eLife, 2018
Synovial sarcoma tumours contain a characteristic fusion protein, SS18-SSX, which drives disease development. Targeting oncogenic fusion proteins presents an attractive therapeutic opportunity.
Gerard L. Brien, David Remillard, Junwei Shi, Matthew L. Hemming, J. Chabon, K. Wynne, E. Dillon, G. Cagney, Guido van Mierlo, Marijke P. A. Baltissen, M. Vermeulen, J. Qi, S. Fröhling, N. Gray, J. Bradner, C. Vakoc, S. Armstrong   +16 more
semanticscholar   +1 more source

The Prognostic Value of Serum Biomarkers in Localized Bone Sarcoma

Translational Oncology, 2016
OBJECTIVE: Certain biomarkers such as the C-reactive protein, serum albumin, and the neutrophils to lymphocyte ratio are of prognostic significance regarding survival in different types of cancers. Data from sarcoma patients are sparse and mainly derived
Ninna Aggerholm-Pedersen, Katja Maretty-Kongstad, Johnny Keller, Steen Baerentzen, Akmal Safwat   +4 more
doaj   +1 more source

Single-cell multi-omics elucidates the role of RPS27-RPS24 fusion gene in osteosarcoma chemoresistance and metabolic regulation

Cell Death Discovery
Osteosarcoma (OS) presents significant treatment challenges due to chemoresistance. This study explores the molecular mechanisms underlying chemoresistance in OS, focusing on the novel fusion gene RPS27-RPS24. Using single-cell multi-omics techniques, we
Zhiwei Tao, Pingan Zou, Zhengxu Yang, Tao Xiong, Zhi Deng, Qincan Chen   +5 more
doaj   +1 more source

Lower limb function and quality of life after ILP for soft-tissue sarcoma

World Journal of Surgical Oncology, 2017
Background Isolated limb perfusion with TNF-alpha and melphalan (TM-ILP) in combination with complete tumor resection is an effective treatment option for non-resectable soft-tissue sarcoma of the extremities, with limb salvage rates greater than 80 ...
Lars Erik Podleska, Nevda Kaya, Farhad Farzaliyev, Christoph Pöttgen, Sebastian Bauer, Georg Taeger   +5 more
doaj   +1 more source

Functional outcome of surgical treatment of adults with extremity osteosarcoma after megaprosthetic reconstruction—single-center experience

Journal of Orthopaedic Surgery and Research, 2019
Background Osteosarcoma is the most common primary malignant bone tumor in adults and is usually located in the long bones. Standard treatment consists of perioperative chemotherapy and radical surgical resection.
Tomasz Goryń, Andrzej Pieńkowski, Bartłomiej Szostakowski, Marcin Zdzienicki, Iwona Ługowska, Piotr Rutkowski   +5 more
doaj   +1 more source

Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma

Modern Pathology, 2018
Integration of morphological, immunohistochemical, and molecular methods is often necessary for the precise diagnosis and optimal clinical management of sarcomas. We have validated and implemented a clinical molecular diagnostic assay, MSK- Fusion Solid,
G. Zhu, R. Benayed, Caleb Ho, Kerry A Mullaney, Purvil Sukhadia, Kelly Rios, Ryan S. Berry, B. Rubin, K. Nafa, Lu Wang, D. Klimstra, M. Ladanyi, M. Hameed   +12 more
semanticscholar   +1 more source

Non-Islet Cell Tumor Hypoglycemia Secondary to a 20 cm Intra-Abdominal Leiomyoma in a Male Patient: A Case Report and Literature Review

Case Reports in Surgery
Non-islet cell tumor hypoglycemia (NICTH) is a rare clinical entity associated with large mesenchymal tumors. Its pathogenesis is most commonly mediated by tumor overproduction of “big” insulin-like growth factor-2.
Michelle D. Lippincott, James D. McDonald, Marilyn M. Bui, Ricardo J. Gonzalez, Rachel K. Voss   +4 more
doaj   +1 more source

Increasing Awareness of Soft-Tissue Sarcoma: Podcast of a Patient–HCP Discussion

Oncology and Therapy
Soft-tissue sarcoma is a rare cancer, making up less than 1% of new cancer diagnoses. They comprise tumours of the connective tissue, and as such can arise in any part of the body and can mimic other conditions. In addition, there are over 80 subtypes of
Gillian Faskin, Sam Hackett
doaj   +1 more source

The Haiti cardiovascular disease cohort: study protocol for a population-based longitudinal cohort

BMC Public Health, 2020
Background Cardiovascular disease (CVD) is the leading cause of mortality among Haitians, having surpassed HIV in the last decade. Understanding the natural history of CVD in Haitians, including the age of onset, prevalence, incidence, and role of major ...
Jean Lookens, Olga Tymejczyk, Vanessa Rouzier, Caleigh Smith, Fabyola Preval, Inddy Joseph, Raynold Jean Baptiste, Joscar Victor, Patrice Severe, Sandra Apollon, Emelyne Dumont, Guyrlaine Forestal, Stephano St. Preux, Vanessa Rivera, Grace Seo, Benedict Charles, Wilson Ariste, Justin Kingery, Jessy Devieux, Serena Koenig, Denis Nash, Daniel Fitzgerald, Monika Safford, Marie Marcelle Deschamps, Jean Pape, Margaret McNairy   +25 more
doaj   +1 more source