Results 1 to 10 of about 516,933 (343)

Genome-wide CRISPR/Cas9 library screening identified ATM signaling network genes as critical drivers for resistance to ATR inhibition in soft-tissue sarcomas: synthetic lethality and therapeutic implications

Experimental Hematology & Oncology, 2023
Soft-tissue sarcoma (STS) are a heterogeneous group of rare tumors with different biological behavior that are fatal in more than 40% of cases, due to their metastatic evolution and inadequate treatment options. ATR inhibition already showed an activity,
M Spalato-Ceruso, A Laroche-Clary, R Perret, Y Valverde, V Chaire, Marie-Alix Derieppe, V Velasco, A Bourdon, A Italiano   +8 more
doaj   +1 more source

Activity of TNT: a phase 2 study using talimogene laherparepvec, nivolumab and trabectedin for previously treated patients with advanced sarcomas (NCT# 03886311)

Frontiers in Oncology, 2023
BackgroundIntratumoral injection of talimogene laherparepvec evokes a cytotoxic immune response. Therefore, the combination of talimogene laherparepvec with trabectedin and nivolumab may have synergistic effects in advanced sarcomas.Patients and ...
Sant P. Chawla, Walter Andree Tellez, Hripsime Chomoyan, Chrysler Valencia, Amir Ahari, Nadezhda Omelchenko, Stefan Makrievski, Don A. Brigham, Don A. Brigham, Victoria Chua-Alcala, Doris Quon, Ania Moradkhani, Erlinda M. Gordon, Erlinda M. Gordon   +13 more
doaj   +1 more source

Outcomes of patients with metastatic gastrointestinal stromal tumors (GIST) treated with multi-kinase inhibitors other than imatinib as first-line treatment

ESMO Open, 2020
Background Imatinib is the standard first-line therapy in metastatic gastrointestinal stromal tumours (GIST). Investigational multi-kinase inhibitors (MKIs) such as nilotinib, dasatinib or masitinib have been tested as first-line therapies in phase II ...
Etienne Rouleau, Axel Le Cesne, Olivier Mir, Pierre Méeus, Julien Adam, Alice Boilève, Armelle Dufresne, Ali Chamseddine, Elise Nassif, Sarah Dumont, Medhi Brahmi, Marie Karanian, Véronique Haddad, Matthieu Faron, Charles Honoré   +14 more
doaj   +1 more source

Age-related sarcoma patient experience: results from a national survey in England

BMC Cancer, 2018
Background Sarcomas are rare, heterogeneous tumours affecting patients of any age. Previous surveys describe that sarcoma patients report a significantly worse experience than those with common cancers.
Eugenie Younger, Olga Husson, Lindsey Bennister, Jeremy Whelan, Roger Wilson, Andy Roast, Robin L Jones, Winette TA van der Graaf   +7 more
doaj   +1 more source

Larotrectinib in a NTRK‐rearranged soft tissue sarcoma in the neoadjuvant setting: A case report

Clinical Case Reports, 2021
Patients with soft tissue sarcomas should be assessed for neurotrophic tropomyosin receptor kinase (NTRK) gene fusions as neoadjuvant treatment with larotrectinib may prevent amputation.
Catherine Percy, Thomas Schubert, Christine Galant, Thomas Kirchgesner, Filomena Mazzeo   +4 more
doaj   +1 more source

Rare aggressive behavior of MDM2-amplified retroperitoneal dedifferentiated liposarcoma, with brain, lung and subcutaneous metastases

Rare Tumors, 2016
Dedifferentiated liposarcoma (DDL) is a histologically pleomorphic sarcoma, traditionally defined as well-differentiated liposarcoma with abrupt transition to high grade, nonlipogenic sarcoma.
Imen Ben Salha, Shane Zaidi, Jonathan Noujaim, Aisha B. Miah, Cyril Fisher, Robin L. Jones, Khin Thway   +6 more
doaj   +1 more source

Soft tissue myoepithelial carcinoma metastatic to the cecum: highlighting an unusual metastatic pattern and the need for diagnostic awareness

Rare Tumors, 2016
Myoepithelial neoplasms of the soft tissues are a rare, heterogeneous group of tumors for which classification continues to evolve. While well defined within salivary glands, they can also arise in viscera and soft tissues, where diagnosis is challenging
Despoina Mourtzoukou, Shane Zaidi, Robin L. Jones, Cyril Fisher, Khin Thway   +4 more
doaj   +1 more source

What Matters to Us: Impact of Telemedicine During the Pandemic in the Care of Patients With Sarcoma Across Scotland

JCO Global Oncology, 2021
PURPOSEIn Scotland, approximately 350 sarcoma cases are diagnosed per year and treated in one of the five specialist centers. Many patients are required to travel long distances to access specialist care.
Holly M. McCabe, Alannah Smrke, Fiona Cowie, Jeff White, Peter Chong, Steven Lo, Ashish Mahendra, Sanjay Gupta, Michelle Ferguson, David Boddie, Walter Mmekka, Lorraine Stirling, Lindsay Campbell, Robin L. Jones, Ioanna Nixon   +14 more
doaj   +1 more source

Metastases of soft tissue sarcoma to the liver: A Historical Cohort Study from a Hospital‐based Cancer Registry

Cancer Medicine, 2020
Background Hepatic metastasis of soft tissue sarcoma is rare compared to lung metastasis, and the literature is scarce. We examined the risk of hepatic metastasis according to the site of occurrence and histological type.
Masanori Okamoto, Masatake Matsuoka, Tamotsu Soma, Ryuta Arai, Hidenori Kato, Toru Harabayashi, Hirohumi Adachi, Toshiki Shinohara, Tamotsu Sagawa, Noriaki Nishiyama, Toshikazu Nambu, Wataru Sakai, Hiroaki Suzuki, Hiroyuki Kato, Hiroaki Hiraga   +14 more
doaj   +1 more source

Predictive and prognostic transcriptomic biomarkers in soft tissue sarcomas

npj Precision Oncology, 2021
Soft tissue sarcomas (STS) are rare and heterogeneous tumours comprising over 80 different histological subtypes. Treatment options remain limited in advanced STS with high rates of recurrence following resection of localised disease.
Eve Merry, Khin Thway, Robin L. Jones, Paul H. Huang   +3 more
doaj   +1 more source