Results 41 to 50 of about 340,819 (312)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive Kaposi's Sarcoma in a 6-month-old African infant: Case Report and Review of the Literature. [PDF]

, 2000
Kaposi's sarcoma (KS), known to exist in Africa for a century now, was rare in children and unknown in the newborn. With the onset of the HIV/AIDS epidemic, a more aggressive, disseminated type of KS (AKS) was recognized. Recently KS was diagnosed in a 6-
Maduhu, I Z, Manji, K P, Amir, H
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Cutaneous sarcomas [PDF]

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2017
SummaryCutaneous sarcomas comprise a heterogeneous group of mesenchymal spindle cell tumors of the dermis and subcutis, one of the best‐known entities being dermatofibrosarcoma protuberans. Other sarcomas addressed in this review include atypical fibroxanthoma, cutaneous undifferentiated pleomorphic sarcoma, leiomyosarcoma, liposarcoma, and ...
Judith, Kohlmeyer, Susanne Annette, Steimle-Grauer, Rüdiger, Hein   +2 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Scandinavian Sarcoma Group: 30 years' experience

, 2009
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldThe article offers information on the Scandinavian Sarcoma Group (SSG) whose aim is to uphold and improve the quality of diagnostics, treatment ...
Bauer, Henrik C. F., Bauer, Henrik, Hall, Kirsten Sundby, Lindholm, Paula, Alvegård, Thor, Rydholm, Anders, Sigurdsson, Svante   +6 more
core   +1 more source

AIDS and Non AIDS-Related Malignant Lymphoma in Tanzania. [PDF]

, 2006
Malignant lymphoma (ML) in HIV patients, are second in frequency to Kaposi's sarcoma (AKS) as AIDS-defining tumors. In Africa the frequency of AIDS-related lymphoma (ARL) is rare and the findings are controversial.
Ekman, Marianne, Lema, Leonard, Biberfeld, P., Kitinya, J, Carneiro, P, Kitinya, James, Kaaya, EE, Kaaya, Ephata E, Biberfeld, P, Linde, A., Castaños-Velez, E, Lema, L, Carneiro, Primo, Lema, L., Kaaya, E.E., Mwakigonja, A., Biberfeld, Peter, Mwakigonja, A, Carneiro, P., Castaños-Velez, Esmeralda, Mwakigonja, Amos, Ekman, M, Linde, Anika, Castaños-Velez, E., Ekman, M., Linde, A   +25 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Angiosarcoma of the Breast with Solitary Metastasis to the Ovary during Pregnancy: An Uncommon Pattern of Metastatic Disease

Case Reports in Oncological Medicine, 2013
Primary de novo angiosarcoma of the breast is an uncommon, aggressive neoplasm. Here, we present a case of a young woman who initially developed primary angiosarcoma of the breast, and subsequently angiosarcoma of the ovary during pregnancy two years ...
Jayson Wang, Cyril Fisher, Khin Thway
doaj   +1 more source

Dermatofibrosarcoma protuberans: from translocation to targeted therapy

Cancer Biology & Medicine, 2015
Dermatofibrosarcoma protuberans (DFSP), the most common dermal sarcoma, is a low-grade, slow growing fibroblastic malignant neoplasm that most frequently affects middle aged adults and is characterized by a high local recurrence rate and a low propensity
Jonathan Noujaim, Khin Thway, Cyril Fisher, Robin L. Jones   +3 more
doaj   +1 more source