Results 51 to 60 of about 214,826 (224)

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Kaposi’s sarcoma-associated herpesvirus T cell responses in HIV seronegative individuals from rural Uganda

Nature Communications, 2021
The T cell response to Kaposi sarcoma-associated herpesvirus is critical to controlling infection and immunopathology but has been poorly explored in immunocompetent patients.
Angela Nalwoga, Romin Roshan, Kyle Moore, Vickie Marshall, Wendell Miley, Nazzarena Labo, Marjorie Nakibuule, Stephen Cose, Rosemary Rochford, Robert Newton, Denise Whitby   +10 more
doaj   +1 more source

Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes

Journal of Intelligent Medicine, EarlyView.
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang, Zhentao Zhou, Lirong Zhu, Wei Liu   +3 more
wiley   +1 more source

Treatment of Kaposi sarcoma herpesvirus-associated multicentric Castleman disease

Hematology/Oncology Clinics of North America, 2018
Synopsis Kaposi sarcoma herpes virus (KSHV)-associated multicentric Castleman disease (MCD) is a rare, polyclonal lymphoproliferative disorder characterized by flares of inflammatory symptoms, edema, cytopenias, lymphadenopathy and splenomegaly ...
K. Lurain, R. Yarchoan, T. Uldrick
semanticscholar   +1 more source

Kaposi sarcoma in a female patient with multiple sclerosis: a case report

Journal of Medical Case Reports
Background Kaposi sarcoma is a vascular neoplasm linked to human herpes virus 8 and presents in four main variants. The development of Kaposi sarcoma, particularly the iatrogenic form, in younger women with autoimmune conditions such as multiple ...
Ahmad Al-Bitar, Ahmad Alkhaledi, Malek Alhamedi   +2 more
doaj   +1 more source

Diagnostic dilemma in Kaposi’s sarcoma

Indian Journal of Plastic Surgery, 2006
Kaposi′s sarcoma is described as cutaneous and extracutaneous neoplasm predominantly affecting older individuals. Though earlier uncommon and endemic to certain African areas, its incidence is on a rise due to infections with human immunodeficiency virus
Rao B.S Satish, Tauro F Leo, Menezes Theobald Leo, B Nandakishore, K Praveen Kumar   +4 more
doaj   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Nonepidemic Kaposi sarcoma: A recently proposed category

JAAD Case Reports, 2017
No abstract available Keywords: HHV-8, human herpesvirus-8; KS, Kaposi sarcoma; Kaposi sarcoma; MSM, men who have sex with men; epidemiology; human herpes virus-8; immunocompetent; nonepidemic.
T. Hinojosa, D. Lewis, Melinda Liu, Gustavo Garza, R. Vangipuram, E. Ramos, J. Salas-Alanis, Z. Nawas, S. Tyring   +8 more
semanticscholar   +1 more source

Multifocal Epithelioid Hemangioma With FOSB Overexpression

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Epithelioid hemangioma (EH) is a benign vascular tumor that most commonly arises on the skin but may also occur in other anatomical locations, including deep soft tissue, bone, visceral organs, penis, and mucosal sites. A hallmark of EH is overexpression of FOS and FOSB, often resulting from various gene fusions.
Phuong Daniels, Aarush Kumar, Alexa Lum, Izabelle Bermudez, Shannon DeSilva, Jonathan Crane, Kristopher McKay   +6 more
wiley   +1 more source