Results 141 to 150 of about 169,719 (379)

Prognostic Utility of the Preoperative Cachexia Index in Patients Undergoing Emergency Laparotomy

Annals of Gastroenterological Surgery, EarlyView.
The preoperative cachexia index, incorporating muscle mass, nutritional status, and inflammation, predicts in‐hospital and one‐year mortality in patients undergoing emergency laparotomy. This simple index may aid in risk stratification and perioperative decision‐making in high‐risk surgical patients. ABSTRACT Aim Emergency laparotomy is associated with
Naoko Fukushima, Takahiro Masuda, Kazuto Tsuboi, Masami Yuda, Keita Takahashi, Fumiaki Yano, Ken Eto   +6 more
wiley   +1 more source

Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function [PDF]

, 2018
Muscle wasting in cancer negatively affects physical function and quality of life. This study investigates amino acid metabolism and the association with muscle mass and function in patients with cancer.In 16 patients with advanced cancer undergoing ...
Deutz, Nicolaas E P, Engelen, Marielle P., Rodriguez, Ramon E., Van der Meij, Barbara S   +3 more
core   +1 more source

Sarcopenia in the elderly [PDF]

Family Practice, 2012
Sarcopenia is the age-related loss of muscle. It leads to loss of muscle power, which in the end results in frailty and disability. There are numerous causes of sarcopenia. Treatment consists of resistance exercise and a leucine-enriched essential amino acid protein supplement. There is an emerging role for testosterone and other anabolic steroids.
openaire   +3 more sources

Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles

Annals of Neurology, EarlyView.
Objective Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.
Christos V. Chalitsios, Jiali Gao, Carol A.C. Coupland, Julia Hippisley Cox, Martin R. Turner, Alexander G. Thompson   +5 more
wiley   +1 more source

Pharmacokinetics, pharmacodynamics and safety of vutiglabridin after multiple oral administrations in healthy female and obese subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee, Hyun Chul Kim, Young Ran Yoon, In‐Jin Jang, Sang‐Ku Yoo, Kyung‐Sang Yu   +5 more
wiley   +1 more source

Comorbid frailty and sarcopenia in older patients after total hip arthroplasty: An observational study

Journal of Joint Surgery and Research
Purpose: Frailty and sarcopenia may progressively worsen physical function, and studies have noted the frequent presence of sarcopenia in patients who undergo total hip arthroplasty (THA).
Takashi Ikeda, Kazunari Ninomiya, Koji Suzuki, Kazuo Hirakawa   +3 more
doaj   +1 more source

Association of Characteristics between Acute Stroke Patients and Sarcopenia: A Cross-Sectional Study [PDF]

운동과학
PURPOSE This study aimed to identify the prevalence of sarcopenia among acute stroke patients, differences in characteristics based on the presence of sarcopenia, the association between functional and sarcopenia factors, and the association between ...
So-Yeong Kim, Byeong-Geun Kim, Se-Ju Park   +2 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Peak expiratory flow mediates the relationship between handgrip strength and timed up and go performance in elderly women, but not men [PDF]

, 2016
OBJECTIVE: The aim of the present study was to verify if there is sex difference in the associations among handgrip strength, peak expiratory flow (PEF) and timed up and go (TUG) test results.
Carvalho, JA, Cendoroglo, MS, Cucato, Gabriel, Franco, FG, Matos, LD, Monteiro-Costa, ML, Nasri, F, Ritti-Dias, RM   +7 more
core   +2 more sources

Characteristics and outcomes of patients with heart failure and history of malignancy: Data from Swedish Heart Failure Registry and the National Cancer Register

European Journal of Heart Failure, EarlyView.
Prevalence and predictors of, and outcome associated with history of cancer in patients with heart failure. AF, atrial fibrillation; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CV, cardiovascular; DM, diabetes mellitus; EF, ejection fraction; GDMT, guideline‐directed medical therapy; GI, gastrointestinal; Hb, haemoglobin; HF ...
Pietro Ameri, Paolo Costa, Lina Benson, Davide Stolfo, Nabil V. Sayour, Charlotta Ljungman, Javed Butler, Stefan D. Anker, Nicolas Girerd, Kalliopi Keramida, Gerasimos Filippatos, Lars H. Lund, Felix Lindberg, Gianluigi Savarese   +13 more
wiley   +1 more source