Results 151 to 160 of about 88,763 (308)

Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In advanced rectal cancer patients receiving total neoadjuvant therapy (TNT), overall tumor response did not differ by diabetes status or metformin use. However, among diabetic patients, metformin use was associated with higher overall complete response rates. These findings suggest a potential benefit of metformin in enhancing TNT response in diabetic
Sergei Bedrikovetski, Mahima Raju, Tracy Fitzsimmons, Ishraq Murshed, Timothy J. Price, Michael Penniment, Sudarsha Selva‐Nayagam, Tarik Sammour   +7 more
wiley   +1 more source

General and Spine-Specific Sarcopenia in Adult Spinal Deformity: a Narrative Overview of Current Strengths and Limitations

Global Spine Journal
Study Design Narrative Review. Objectives Recent studies have separated assessment of sarcopenia into two main categories within spine surgery: (1) general sarcopenia assessing systemic muscle degeneration and (2) spine-specific sarcopenia assessing ...
Tim T. Bui BS, Karan Joseph BS, Alexander T. Yahanda MD, Andrew R. Findlay MD, Alekos A. Theologis MD, Mitsuru Yagi MD, PhD, Javier Pizones MD, PhD, Corey Walker MD, Elizabeth Lord MD, Robert K. Eastlack MD, Ferran Pellisé MD, Joseph A. Osorio MD, PhD, Kristen Jones MD, Miranda van Hooff PhD, Laurel Blakemore MD, Suken A. Shah MD, Serena Hu MD, Marinus de Kleuver MD, PhD, Michael Kelly MD, Christopher Ames MD, Camilo A. Molina MD   +20 more
doaj   +1 more source

Low Free Testosterone Is Independently Associated With Long‐Term Mortality in Men With Chronic Spinal Cord Injury

Andrology, EarlyView.
ABSTRACT Background Testosterone deficiency is highly prevalent in men with chronic spinal cord injury (SCI) and is associated with obesity, sarcopenia, systemic inflammation, and metabolic dysfunction. However, the independent prognostic role of low testosterone in long‐term mortality in this population remains unclear.
D. Tienforti, L. Spagnolo, C. Moretto, G. Terrana, R. Di Geronimo, E. Perfetto, G. Felzani, M. G. Baroni, A. Barbonetti   +8 more
wiley   +1 more source

Association of sarcopenia with generalized anxiety disorder in Korean middle-aged and older adults: Results from the Korea National Health and Nutrition Examination Survey in 2022.

PLoS ONE
We highlighted sarcopenia's association with psychiatric disorders, including generalized anxiety disorder (GAD), and aimed to explore correlations between the detection and prevention of GAD using population-based data of middle-aged and older Korean ...
Hye-Eun An, Hye-Su Park, Chang Shik Yin
doaj   +1 more source

Glucagon‐like peptide‐1 receptor agonists and muscle strength changes in older adults: Risks beyond muscle mass reductions

British Journal of Pharmacology, EarlyView.
Abstract Gastric inhibitory polypeptide (GIP)/Glucagon‐like peptide‐1 (GLP‐1) receptor agonists are increasingly prescribed for the management of obesity and type 2 diabetes, yet research pertinent to their effects on muscle health is limited. Considering the central role of muscle strength as a sarcopenia component, this article summarizes emerging ...
Konstantinos Prokopidis
wiley   +1 more source

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer

British Journal of Pharmacology, EarlyView.
Background and Purpose Musclin (osteocrin) is a skeletal muscle‐derived peptide that has been implicated in cardioprotective signalling pathways. Its relevance in cancer patients, who frequently experience muscle wasting and cardiotoxicity, remains unclear. This study aimed to determine whether circulating Musclin levels reflect functional capacity and
Jannek Brauer, Daniel Finke, Sebastian Romann, Norbert Frey, Joerg Heineke, Lorenz H. Lehmann   +5 more
wiley   +1 more source

Sarcopenia is associated with the neutrophil/lymphocyte and platelet/lymphocyte ratios in operable gastric cancer patients: a prospective study [PDF]

, 2018
Ji Lin,1,* Weiteng Zhang,1,* Yunshi Huang,1 Weisheng Chen,1 Ruisen Wu,1 Xiaodong Chen,1 Neng Lou,2 Pengfei Wang1 1Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China; 2Department of ...
Zhang W, Lou N, Wang P, Huang Y, Chen W, Wu R, Lin J, Chen X   +7 more
core  

The insulin‐like growth factor system and the progression of renal complications of type 2 diabetes

Diabetic Medicine, EarlyView.
Abstract Aims Chronic kidney disease is associated with dysregulation of the insulin‐like growth factor (IGF) system. Alterations in IGF bioavailability, driven by IGF binding proteins (IGFBPs), may influence the decline in renal function. However, the longitudinal relationship between baseline IGF‐I, IGF‐II, IGFBPs and progression of kidney ...
Adrian Heald, Yasitha lllangasekera, Andreas Matheou, Ram Prakash Narayanan, Stephen White, Hellena Habte‐Asres, Abigail Lay, Liliana Shalamanova, William Ollier, Graham A. Hitman, Ritwika Mallik, Philip A. Kalra, Martin Whyte, J. Martin Gibson   +13 more
wiley   +1 more source

The burden of diabetic foot ulcers in a multi‐ethnic Asian cohort

Diabetic Medicine, EarlyView.
Abstract Aims Diabetic foot ulcers (DFUs) are a major source of morbidity among individuals with diabetes mellitus (DM), imposing a substantial burden on healthcare systems. Our institution established a multidisciplinary service aiming to facilitate early specialist intervention for DFU management.
Zongwen Wee, Yong Mong Bee, Sueziani Binte Zainudin   +2 more
wiley   +1 more source

Causal Associations Between Sarcopenia and Gestational Diabetes Mellitus [PDF]

Yihong Huang,1,2,* Shanshan Zhao,1,2,* Jiajun Hong,1,2 Lixia Shen,1,2 Zilian Wang,1,2 Dongyu Wang1,2 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China ...
Shen L, Huang Y, Zhao S, Hong J, Wang D, Wang Z   +5 more
core   +1 more source