Results 221 to 230 of about 105,256 (302)

Immunomodulatory Peptide LW‐9 Enhances Doxorubicin Efficacy by Downregulating PD‐L1 and Promoting Intratumoral T‐Cell Responses in Murine Breast Cancer

Immunology, EarlyView.
LW‐9, a peptide derived from Phoneutria nigriventer venom, enhances antitumor immunity in a murine breast cancer model by remodelling the tumour microenvironment. Treatment reduces PD‐L1 expression while increasing CD3+ and GITR+ T‐cell infiltration, resulting in delayed tumour progression, particularly when combined with doxorubicin.
Ingrid Mayara Cavalcante Trevisan, Cibele Pereira Mariano, Sabrina Carvalho Brunelli, Gabriel da Silva Cordeiro, Jessika Takaki, Valquiria Aparecida Matheus, Liana Verinaud, Catarina Rapôso   +7 more
wiley   +1 more source

Association of Sarcopenia With Global, Motor, Cognitive, and Swallowing Function Prognosis in Stroke Patients: A Systematic Review and Meta-Analysis. [PDF]

Brain Behav
Xie D, Ma M, Chen L.
europepmc   +1 more source

Glycated albumin: An old yet new biomarker in people with diabetes and the potential for novel applications

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Glycated albumin (GA), the product of nonenzymatic glycation of serum albumin, reflects the mean glucose levels over the preceding approximately 2 weeks, bridging the gap between daily self‐monitoring of blood glucose and the roughly 3‐month window covered by glycated hemoglobin (HbA1c) measurement.
Masakazu Aihara, Naoto Kubota
wiley   +1 more source

The DOAC‐FRAIL Study—Same Dose, Different Story: Prevalence of Deviant Direct Oral Anticoagulant Levels in Nursing Home Residents

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Direct oral anticoagulants (DOACs) are prescribed using fixed dosing regimens, despite limited evidence on their pharmacokinetic behavior in nursing home residents. Participants and Setting One hundred nursing home residents are receiving apixaban, rivaroxaban, dabigatran, or edoxaban in multiple long‐term care facilities in the ...
Irme S. Franssen, Melanie J. de Jong, Lars Visseren, Daan Teerds, Dave Hellenbrand, Yvonne Henskens, Henri Spronk, Daisy J. A. Janssen, Dionne C. W. Braeken, Sander M. J. van Kuijk, Kristien Winckers, Fabienne J. H. Magdelijns   +11 more
wiley   +1 more source

The Mean and Variability of Morning Hour Activity Over 2–3 Days Predict 5‐Year Mortality and Frailty Risk in a National Sample of Older Adults

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Activity pattern features measured by continuous accelerometry are strongly associated with frailty, making accelerometry a promising, scalable screening tool for frailty. However, adherence to typical 5–7 day wear protocols decreases with age, reducing feasibility.
Megan Huisingh‐Scheetz, Sylvia Brown, Michelangelo Pagan, Cassidy Cabrera, Daniel Rubin, Nabiel Mir, Maria Lucia Madariaga, L. Philip Schumm, Kristen Wroblewski, Donald Hedeker   +9 more
wiley   +1 more source

Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Down syndrome (DS) entails widespread age‐related functional decline affecting multiple organ systems, including genetically determined early‐onset Alzheimer disease (DSAD), resulting in an increased vulnerability to frailty early in life.
Georg Nübling, Lena Marth, Katja Sandkühler, Anna Stockbauer, Elisabeth Wlasich, Alexander Jäck, Olivia Wagemann, Julia Kustermann, Steffen Halbgebauer, Hayrettin Tumani, Günter Höglinger, Johannes Levin   +11 more
wiley   +1 more source

European Consortium for Lipodystrophies consensus definition and classification framework for monogenic lipodystrophy

Journal of Internal Medicine, EarlyView.
Abstract Lipodystrophy comprises a heterogeneous group of disorders characterized by reduced adipose tissue often associated with severe metabolic complications. Lipodystrophy may be genetic, acquired, or secondary to medical therapies initiated for other conditions.
Robert K. Semple, Martin Wabitsch, Baris Akinci, Saif Alyaarubi, Marjoleine F. Broekema, Rebecca J. Brown, Giovanni Ceccarini, Carolina Cecchetti, Solaf M. Elsayed, Antía Fernández‐Pombo, Alessandra Gambineri, Ingrid M. Jazet, Lotte Kleinendorst, Konstanze Miehle, Elif A. Oral, Flavia Prodam, Ferruccio Santini, David B. Savage, Nadia Shaukat Ali, Ekaterina Sorkina, Magdalena Szopa, Marie‐Christine Vantyghem, Camille Vatier, Corinne Vigouroux, Julia von Schnurbein, David Araújo‐Vilar   +25 more
wiley   +1 more source

Association Among Eating Speed, Dietary Diversity, and Fat‐Free Mass Index in Adults

Journal of Oral Rehabilitation, EarlyView.
This study examined the associations among body composition indices, eating speed, and dietary diversity. Dietary diversity was positively associated with muscle mass in men and negatively associated with body fat mass index in women, while fast eating was significantly associated with fat‐free mass index.
Takatoshi Hiroshimaya, Komei Iwai, Marika Marutani, Tetsuji Azuma, Takatoshi Yonenaga, Koichiro Tabata, Kazutoshi Watanabe, Michiya Ohno, Mitsuru Seishima, Takaaki Tomofuji, Naofumi Tamaki   +10 more
wiley   +1 more source

Sarcopenia in Indian adults with type 2 diabetes: a systematic review and meta-analysis of prevalence and associated factors. [PDF]

BMJ Open
Raj S, Suvarna R, Thunga G, B S V, Shetty S.   +4 more
europepmc   +1 more source

Masticatory Performance and its Relationship With Sarcopenia, Frailty and Functional Outcomes in Hospitalized Older Adults: A Prospective Cohort Study

Journal of Oral Rehabilitation, EarlyView.
In 217 patients aged ≥ 70 years admitted to geriatric rehabilitation, poor oral function assessed by masticatory performance was common and often occurred without sarcopenia or frailty. Its independent association with functional outcomes suggests that pragmatic bedside assessment of masticatory performance adds value to routine geriatric assessment in
Seraina Netzer, Nicole Tochtermann, Martin Schimmel, Stephanie Naef, Ramona Buser, Nicola Lucas Merz, Andreas Limacher, Anna Katharina Eggimann   +7 more
wiley   +1 more source