Results 41 to 50 of about 131,783 (290)

Drug‐related sarcopenia as a secondary sarcopenia

Geriatrics & Gerontology International, 2023
Sarcopenia has a significant impact on falls, physical function, activities of daily living, and quality of life in older adults, and its prevention and treatment are becoming increasingly important as the global population ages. In addition to primary age‐related sarcopenia, activity‐related sarcopenia, disease‐related sarcopenia, and nutrition ...
openaire   +2 more sources

Prognostic Value of Computed Tomography : Measured Parameters of Body Composition in Primary Operable Gastrointestinal Cancers [PDF]

, 2017
Professor Graeme Murray, Department of Pathology, University of Aberdeen provided us access to the colorectal cancer pathology databases from which the colorectal component of the research was based.
Black, Douglas, Hamoodi, Zaid, Loudon, Malcolm, MacKay, Craig, Nanthakumaran, Shayanthan, Park, Kenneth G. M., Ramsay, George, Richards, Colin H.   +7 more
core   +2 more sources

Prevalence and associated factors of possible sarcopenia and sarcopenia: findings from a Chinese community-dwelling old adults cross-sectional study

BMC Geriatrics, 2022
Purpose To describe the prevalence and analyse the associated factors of possible sarcopenia and sarcopenia among community-dwelling old adults in China, in order to provide effective strategies for early prevention and treatment of sarcopenia.
Jiazhi Wang, Changge Liu, Lin Zhang, Ning Liu, Lei Wang, Jingqiong Wu, Yizhao Wang, Huimin Hao, Longjun Cao, Shilei Yuan, Liping Huang   +10 more
doaj   +1 more source

Tumour-derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour-bearing mice [PDF]

, 2018
BACKGROUND: Cancer cachexia is a metabolic wasting syndrome that is strongly associated with a poor prognosis. The initiating factors causing fat and muscle loss are largely unknown. Previously, we found that leukaemia inhibitory factor (LIF) secreted by
Alter, Aulino, Ben-David, Bilir, Bonetto, Bonetto, Cornwell, Delitto, Delitto, Dingemans, Fearon, Fearon, Fukawa, Gascan, Graf, Haehling, He, Iseki, Jackman, Jo, Johns, Judge, Kir, Lerner, Loumaye, Martin, Mori, Mori, Onesti, Penna, Petruzzelli, Rubin, Sagar, Schafer, Seto, Stephens, Talbert, Tseng, Villiger, Zhang   +39 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Factors That Improve Chest Computed Tomography-Defined Sarcopenia Prognosis in Advanced Non-Small Cell Lung Cancer

Frontiers in Oncology, 2021
BackgroundWhether muscle strength and physical performance should be components of sarcopenia remains controversial. This study evaluated the skeletal muscle index derived from computed tomography images at the 12th thoracic vertebra level (T12 SMI ...
Ming Yang, Ming Yang, Ming Yang, Lingling Tan, Lingling Xie, Song Hu, Dan Liu, Jing Wang, Weimin Li, Weimin Li, Weimin Li   +10 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

A pilot study of temsirolimus and body composition. [PDF]

, 2013
PurposeBody weight and composition play a role in cancer etiology, prognosis, and treatment response. Therefore, we analyzed the weight, body composition changes, and outcome in patients treated with temsirolimus, an mTor inhibitor that has weight loss ...
Janku, Filip, Kurzrock, Razelle, Naing, Aung, Parsons, Henrique A, Tsimberidou, Apostolia M, Veasey-Rodrigues, Heloisa, Wheler, Jennifer J   +6 more
core   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Model for End‐Stage Liver Disease/Pediatric End‐Stage Liver Disease exception policy and outcomes in pediatric patients with hepatopulmonary syndrome requiring liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Hepatopulmonary syndrome (HPS) is associated with increased waitlist mortality in liver transplantation (LT) candidates. Children with HPS are granted Model for End‐Stage Liver Disease (MELD)/Pediatric End‐Stage Liver Disease (PELD) exception points for waitlist prioritization in the United States based on criterion developed for adults.
Muhammad H. Raza, Yong Kwon, Pierre Kobierski, Asish C. Misra, Angelina Lim, Cameron Goldbeck, Kambiz Etesami, Rohit Kohli, Juliet Emamaullee   +8 more
wiley   +1 more source