Results 61 to 70 of about 110,963 (356)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in Oncology, 2021 BackgroundWhether muscle strength and physical performance should be components of sarcopenia remains controversial. This study evaluated the skeletal muscle index derived from computed tomography images at the 12th thoracic vertebra level (T12 SMI ...
Ming Yang +10 more
doaj +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
EFFECTS OF LEUCINE SUPPLEMENTATION AND RESISTANCE TRAINING TO COUNTERACT SARCOPENIA
, 2022 openLa sarcopenia, ossia la diminuzione di forza e/o massa muscolare che si verifica con l’invecchiamento, rappresenta una realtà sempre più frequente tra le classi anziane e di interesse per i sistemi sanitari.
TOMMASINI, ENRICO
core
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
, 2017 Objectives: There is no gold standard in diagnosing sarcopenia. We aimed to assess the validity of screening sarcopenia using SARC-F (sluggishness, assistance in walking, rise from a chair, climb stairs, falls).
季瑋珠;楊榮森 +1 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective Knee osteoarthritis (OA) commonly affects individuals with type 2 diabetes (T2DM) and is associated with increased risk of diabetes‐related complications. To better understand potential mechanisms, we examined the association between symptomatic knee OA and glycemic control in individuals with T2DM.
Lauren K. King +10 more
wiley +1 more source
Mitochondrial regulation in the tumor microenvironment: targeting mitochondria for immunotherapy
Frontiers in ImmunologyMitochondrial regulation plays a crucial role in cancer immunity in the tumor microenvironment (TME). Infiltrating immune cells, including T cells, natural killer (NK) cells, and macrophages, undergo mitochondrial metabolic reprogramming to survive the ...
Minseo Ahn +6 more
doaj +1 more source
The Relationship of Sleep Duration with Obesity and Sarcopenia in Community-Dwelling Older Adults
, 2017 Background: Numerous studies have reported the relationship between sleep duration and obesity in elderly adults; however, little is known about the relationship of sleep duration and sarcopenia.
王儷穎;簡盟月;陳錫中 +1 more
core +1 more source
Exercise–microbiota interactions in aging-related sarcopenia [PDF]
, 2022 Sarcopenia, the age-related loss of skeletal muscle mass and function, is associated with increasing burden of frailty, disability, and mortality for our aging society.
Burtscher J. +4 more
core +1 more source