Results 71 to 80 of about 169,719 (379)

The Conceptual Definition of Sarcopenia: Delphi Consensus from the Global Leadership Initiative in Sarcopenia (GLIS)

Age and Ageing
Importance Sarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on the definition exists.
B. Kirk, Peggy M. Cawthon, H. Arai, J. A. Ávila-Funes, R. Barazzoni, Shalender Bhasin, Ellen F. Binder, O. Bruyère, Tommy Cederholm, Liang-Kung Chen, C. Cooper, Gustavo Duque, R. Fielding, Jack Guralnik, Douglas P. Kiel, Francesco Landi, J. Reginster, A. Sayer, Marjolein Visser, Stephan von Haehling, Jean Woo, A. Cruz-Jentoft   +21 more
semanticscholar   +1 more source

Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines

Cells, 2022
Obesity and ageing place a tremendous strain on the global healthcare system. Age-related sarcopenia is characterized by decreased muscular strength, decreased muscle quantity, quality, and decreased functional performance.
J. Bilski, P. Pierzchalski, M. Szczepanik, J. Bonior, J. Zoladz   +4 more
semanticscholar   +1 more source

Prognostic Value of Computed Tomography : Measured Parameters of Body Composition in Primary Operable Gastrointestinal Cancers [PDF]

, 2017
Professor Graeme Murray, Department of Pathology, University of Aberdeen provided us access to the colorectal cancer pathology databases from which the colorectal component of the research was based.
Black, Douglas, Hamoodi, Zaid, Loudon, Malcolm, MacKay, Craig, Nanthakumaran, Shayanthan, Park, Kenneth G. M., Ramsay, George, Richards, Colin H.   +7 more
core   +2 more sources

Differences in Insulin-Like Growth Factor-1 and Tumor Necrosis Factor-Α Serum Levels on Various Degree of Sarcopenia in Elderly Patients: A Cross-Sectional Study

Jurnal Penyakit Dalam Indonesia, 2023
Introduction. Sarcopenia is a phenomenon of progressive decline in muscle function that occurs due to the aging process. Insulin-like growth factor-1 (IGF-1) and tumor necrosis factor-α (TNF-α) have an important role in the occurrence of sarcopenia ...
Auliangi Tamayo, Roza Mulyana, Rose Dinda Martini   +2 more
doaj   +1 more source

Prevalence of depression in patients with sarcopenia and correlation between the two diseases: systematic review and meta‐analysis

Journal of Cachexia, Sarcopenia and Muscle, 2022
Depression may be the most common cause of emotional distress later in life and can significantly reduce the quality of life in elderly individuals.
Zhenzhen Li, X. Tong, Yao Ma, Ting Bao, J. Yue   +4 more
semanticscholar   +1 more source

Implications of skeletal muscle loss for public health nutrition messages:a brief report [PDF]

, 2015
Age-related skeletal muscle loss, sarcopenia, cachexia and wider malnutrition (under nutrition) are complex in aetiology with interaction of clinical, social and economic factors.
Levy, Louis B, Welch, Ailsa A
core   +1 more source

Mitochondrial regulation in the tumor microenvironment: targeting mitochondria for immunotherapy

Frontiers in Immunology
Mitochondrial regulation plays a crucial role in cancer immunity in the tumor microenvironment (TME). Infiltrating immune cells, including T cells, natural killer (NK) cells, and macrophages, undergo mitochondrial metabolic reprogramming to survive the ...
Minseo Ahn, Minseo Ahn, Akhtar Ali, Akhtar Ali, Jae Ho Seo, Jae Ho Seo, Jae Ho Seo   +6 more
doaj   +1 more source

Sarcopenia and Sarcopenic Obesity and Mortality Among Older People

JAMA Network Open
Key Points Question What is the prevalence of sarcopenia and sarcopenic obesity, and are these conditions associated with all-cause mortality? Findings In this cohort study of 5888 older adults, 2.2% had confirmed sarcopenia; by applying the sarcopenic ...
E. Benz, A. Pinel, C. Guillet, F. Capel, Bruno Pereira, M. De Antonio, M. Pouget, A. Cruz-Jentoft, Doris Eglseer, E. Topinková, R. Barazzoni, Fernando Rivadeneira, M. Ikram, Marinka Steur, T. Voortman, J. Schoufour, P. J. Weijs, Y. Boirie   +17 more
semanticscholar   +1 more source

Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update

Cells, 2022
Sarcopenia is generally an age-related condition that directly impacts the quality of life. It is also related to chronic diseases such as metabolic dysfunction associated with diabetes and obesity.
G. E. Jiménez-Gutiérrez, L. Martínez-Gómez, C. Martinez-Armenta, C. Pineda, G. Martínez-Nava, A. López-Reyes   +5 more
semanticscholar   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source