Results 171 to 180 of about 6,398 (198)

UXT plays dual opposing roles on SARM-induced apoptosis [PDF]

FEBS Letters, 2013
Apoptosis is a vital defense mechanism for the clearance of infected cells. Ubiquitously expressed transcript (UXT), which exists in two isoforms (V1 and V2), interact with both apoptotic and cellular proteins. By yeast two-hybrid analysis, we found that
Bernadette Byrne, Porkodi Panneerselvam, Jeak Ling Ding   +2 more
exaly   +2 more sources

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Abstract OT1-02-02: A phase 1/2 study to evaluate the safety and efficacy of EP0062, an oral Selective Androgen Receptor Modulator (SARM), for the treatment of AR+/HER2-/ER+ advanced breast cancer

Cancer Research, 2023
There is growing interest in targeting the androgen receptor (AR) in advanced/metastatic breast cancer. It has been recently demonstrated preclinically that AR activation, rather than AR suppression, exerts potent antitumor activity across a number of ...
E. Lim, E. Hamilton, C. Palmieri, H. Arkenau, S. Brook, G. Fisher, Andrew Mazur   +6 more
semanticscholar   +1 more source

A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+/HER2- Metastatic Breast Cancer.

Clinical Breast Cancer, 2021
INTRODUCTION/BACKGROUND This first-in-human, phase 1 study aimed to characterize the safety, tolerability, maximum tolerated dose (MTD), pharmacokinetic (PK) profile, and antitumor activity of RAD140, an oral selective androgen receptor (AR) modulator ...
P. Lorusso, E. Hamilton, Cynthia X. Ma, N. Vidula, R. Bagley, S. Troy, M. Annett, Zi-Yang Yu, M. Conlan, A. Weise   +9 more
semanticscholar   +1 more source

SARM: Stage-Aware Reward Modeling for Long Horizon Robot Manipulation

arXiv.org
Large-scale robot learning has made progress on complex manipulation tasks, yet long horizon, contact rich problems, especially those involving deformable objects, remain challenging due to inconsistent demonstration quality.
Qianzhong Chen, Justin Yu, Mac Schwager, Pieter Abbeel, Fred Shentu, Philipp Wu   +5 more
semanticscholar   +1 more source

ANALISA SENTIMEN TERHADAP BELAJAR ONLINE PADA MASA COVID-19 MENGGUNAKAN ALGORITMA SUPPORT VECTOR MACHINE BERBASIS PARTICLE SARM OPTIMIZATION

Jurnal Informatika Kaputama (JIK), 2021
Coronavirus 19 (COVID-19) merupakan infeksi virus menular yang saat ini sudah merambah ke berbagai negara salah satunya di Indoenesia. Pemantauan penyebaran COVID-19 di Indonesia ditangani langsung oleh Pemerintah Indonesia terutama. Pemerintah Indonesia
H. Hermanto, Astrid Noviriandini
semanticscholar   +1 more source

From gains to gaps? How Selective Androgen Receptor Modulator (SARM) YK11 impact hippocampal function: In silico, in vivo, and ex vivo perspectives.

Chemico-Biological Interactions
Selective Androgen Receptor Modulators (SARMs), particularly (17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic-acid-methyl-ester (YK11), are increasingly popular among athletes seeking enhanced performance ...
M. M. M. Dahleh, V. Bortolotto, S. Boeira, H. Segat, G. Guerra, M. Prigol   +5 more
semanticscholar   +1 more source

A comprehensive gas chromatography electron ionization high resolution mass spectrometry study of a new steroidal selective androgen receptor modulator (SARM) compound S42.

Journal of Mass Spectrometry
The synthetic 20-keto-steroid S42 (1) demonstrated selective androgen receptor modulator (SARM) properties in preclinical studies and, consequently, received growing attention also in the context of sports drug testing programs. Fundamental understanding
Hui-Chung Wen, Tobias Wilczek, Jörg M. Neudörfl, Felicitas Wagener, T. Piper, M. Thevis, Mathias Schäfer   +6 more
semanticscholar   +1 more source

SARM: LLM-Augmented Semantic Anchor for End-to-End Live-Streaming Ranking

arXiv.org
Large-scale live-streaming recommendation requires precise modeling of non-stationary content semantics under strict real-time serving constraints.
Ruo-Chen Yang, Yue-Yang Liu, Z. Zhuang, Chang-Xin Lao, Yu-Hui Zhang, Jiang-Xia Cao, Jia Xu, Xiang Chen, Hao-Ke Xiao, Xiang-Yu Wu, Xiao-You Zhou, Xiao Lv, Shuang Yang, Tin-gwen Liu, Zhao-Jie Liu, Han Li, Kun Gai   +16 more
semanticscholar   +1 more source

Celastrol attenuates incision‐induced inflammation and pain associated with inhibition of the NF‐&kgr;B signalling pathway via SARM

Life Science, 2018
Aim: This study aimed to investigate whether celastrol (CEL) could alleviate incision‐induced pain and decipher its possible mechanism. Materials and methods: Sprague‐Dawley rats were randomly divided into five groups: naïve, vehicle, CEL (5 &mgr;g/paw ...
Xu-Hui Chen, Bo Zhang, Jiayan Li, Miaomiao Feng, Yue Zhang, Wen-Long Yao, Chuan-Han Zhang, L. Wan   +7 more
semanticscholar   +1 more source

Studies on the in vivo metabolism of the SARM YK11: Identification and characterization of metabolites potentially useful for doping controls.

Drug Testing and Analysis, 2018
A steroidal compound was recently detected in a seized black market product and was identified as (17α,20E)-17,20-[(1-methoxyethylidene) bis (oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11).
T. Piper, Josef Dib, Marlen Putz, G. Fusshöller, Valentin Pop, Andreas Lagojda, Dirk Kuehne, H. Geyer, W. Schänzer, M. Thevis   +9 more
semanticscholar   +1 more source