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La sarna del conejo

, 1990
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Artificial Neutrophil-Mediated CEBPA-saRNA Delivery to Ameliorate ALI/ARDS

ACS Applied Materials & Interfaces
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) still faces great challenges due to uncontrollable inflammation disorders, complicated causes of occurrence, and high mortality.
Lingmin Zhang, Aiping Qin, Shunqing Tang   +2 more
exaly   +2 more sources

A novel alphavirus-based saRNA platform for enhanced vaccination efficacy and organ-specific targeting.

Vaccine
Self-amplifying RNA (saRNA), derived from alphaviruses, encodes nonstructural proteins (NSP1-4) that form a replicase complex, enabling prolonged and amplified protein expression at lower doses than conventional mRNA. However, its high immunogenicity and
Zhen Sun, Yuxiao Liu, Haoyi Zhang, Ting Ge, Yuting Pan, Yang Liu, Miaomiao Wu, Tao Shan, Guoqiang Zhu, Qi Wu, Kangming Chen   +10 more
semanticscholar   +1 more source

Abstract 936: HPV-related cancer model development and its application in the efficacy evaluation of a saRNA cancer vaccine

Cancer Research
Cancer remains one of the most serious diseases threatening human health, influenced by many factors, such as genetic, physical, chemical and biological factors. Among various cancers, a special subtype is associated with viral infections.
Zhongbao Song, Guangxu Ding, Anran Xia, Lihuan Bai, Wanqing Ma, Qiuhong Li, Xu Chen, Zhixiang Zhang, Qingyang Gu   +8 more
semanticscholar   +1 more source

Tribal mobilization for religious identity and political space: ongoing demand for inclusion of Sarna-Tribal religion in the census of India

Inter-Asia Cultural Studies
The public mobilization of religious communities to acquire political space has been a heated discussion among scholars worldwide. Research reveals a long history of religious communities participating in political movements.
Nandini Tank, Upendar Gundala, Seemita Mohanty   +2 more
semanticscholar   +1 more source

The Sarna Movement in Jharkhand

2017
Politics in Jharkhand has always drawn inspiration from its status as a Schedule Five Area. It was designated as such after successive agitations by Adivasis in colonial times made it necessary for distinct laws related to land use and tenure to be applicable in the region.
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Safety, immunogenicity, and optimal dosing of VLPCOV-02, a SARS-CoV-2 saRNA vaccine with modified 5-methylcytosine base

iScience
Summary Variant-adapted vaccines are becoming increasingly important for continued COVID-19 prevention. Part 1 of the phase 1/2 study with VLPCOV-02, a lipid nanoparticle-encapsulated, self-amplifying RNA (saRNA) vaccine with a modified 5-methylcytosine (
M. Aboshi, D. Kawakami, K. Kono, Ayae Nishiyama, T. Nogimori, Yuko Sunada, Kenta Matsuda, T. Sekida, S. Suga, Jonathan F. Smith, N. Sato, Takuya Yamamoto, Wataru Akahata   +12 more
semanticscholar   +1 more source

Mechanism of Notch1-saRNA-1480 reversing androgen sensitivity in human metastatic castration-resistant prostate cancer

International Journal of Molecular Medicine, 2020
The aim of the present study was to explore the mechanism by which Notch1-small activating (sa)RNA restored androgen sensitivity in human metastatic castration-resistant prostate cancer (CRPC).

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First-in-human phase I trial of small activating RNA (saRNA) oligonucleotide MTL-CEBPA in combination with sorafenib in patients with advanced hepatocellular carcinoma (HCC).

, 2020
554Background: MTL-CEBPA is the first saRNA to enter clinical trials and targets the transcription factor C/EBPα, a master regulator of myeloid cell differentiation.
D. Sarker, M. Sodergren, E. Plummer, B. Basu, T. Meyer, Kai-Wen Huang, T. Evans, D. Spalding, Yuk Ting Ma, D. Palmer, C. Chee, D. Pinato, V. Reebye, D. McVeigh, N. Raulf, J. Vasara, P. Andrikakou, R. Habib, D. Blakey, N. Habib   +19 more
semanticscholar   +1 more source

Self-Assembled saRNA Delivery System Based on Rolling Circle Transcription for Aptamer-Targeting Cancer Therapy.

ACS Applied Bio Materials, 2019
With the capacity of gene promotion, RNA activation (RNAa) has been supposed to be a powerful technique in the field of biomedicine, especially in an antitumor aspect. However, one of the pressing challenges for clinical application is how to efficiently
Tengfei Wang, Shanni Hong, Yu Luo, Haiyin Lv, Ye Zhang, R. Pei   +5 more
semanticscholar   +1 more source