Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development [PDF]
Pathogens, 2023 The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA ...
Barbara Schnierle +2 more
exaly +4 more sources
Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines. [PDF]
Mol Ther Nucleic Acids, 2023 To be effective, RNA vaccines require both in situ translation and the induction of an immune response to recruit cells to the site of immunization. These factors can pull in opposite directions with the inflammation reducing expression of the vaccine ...
Tregoning JS +13 more
europepmc +5 more sources
Self-Amplifying RNA: A Second Revolution of mRNA Vaccines against COVID-19 [PDF]
VaccinesSARS-CoV-2 virus, the causative agent of COVID-19, has produced the largest pandemic in the 21st century, becoming a very serious health problem worldwide.
Cristian Smerdou +2 more
exaly +4 more sources
Self-Amplifying RNA: Advantages and Challenges of a Versatile Platform for Vaccine Development. [PDF]
VirusesSelf-amplifying RNA is synthetic nucleic acid engineered to replicate within cells without generating viral particles. Derived from alphavirus genomes, saRNA retains the non-structural elements essential for replication while replacing the structural ...
Vallet T, Vignuzzi M.
europepmc +4 more sources
Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids [PDF]
Molecular Therapy - Nucleic Acids, 2018 Advances in RNA technology during the past two decades have led to the construction of replication-competent RNA, termed replicons, RepRNA, or self-amplifying mRNA, with high potential for vaccine applications.
Thomas Ebensen +2 more
exaly +6 more sources
Self-amplifying RNA (saRNA) and circular RNA (circRNA) vaccines: Progress, evidence gaps, and translational pathways for durable and scalable immunization. [PDF]
Hum Vaccin ImmunotherSelf-amplifying RNA (saRNA) and circular RNA (circRNA) are emerging vaccine modalities that extend conventional, non-replicating mRNA platforms. Self-amplifying RNA encodes a replicase that amplifies intracellular RNA templates, enabling high antigen ...
Okechukwu Paul-Chima U +4 more
europepmc +2 more sources
An Update on Self-Amplifying mRNA Vaccine Development
Vaccines, 2021 This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)).
Andy Geall +2 more
exaly +3 more sources
A self-amplifying RNA vaccine provides protection in a murine model of bubonic plague. [PDF]
Front Microbiol, 2023 Mice were immunized with a combination of self-amplifying (sa) RNA constructs for the F1 and V antigens of Yersinia pestis at a dose level of 1 μg or 5 μg or with the respective protein sub-units as a reference vaccine.
Shattock RJ +11 more
europepmc +2 more sources
A bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses. [PDF]
Front ImmunolIntroductionYellow fever (YFV) and Zika (ZIKV) viruses cause significant morbidity and mortality, despite the existence of an approved YFV vaccine and the development of multiple ZIKV vaccine candidates to date.
Battisti P +16 more
europepmc +2 more sources
Trans-Amplifying RNA: A Journey from Alphavirus Research to Future Vaccines
VirusesReplicating RNA, including self-amplifying RNA (saRNA) and trans-amplifying RNA (taRNA), holds great potential for advancing the next generation of RNA-based vaccines.
Tim Beissert
exaly +3 more sources