Results 31 to 40 of about 57,349 (269)

Nonviral delivery of self-amplifying RNA vaccines [PDF]

Proceedings of the National Academy of Sciences, 2012
Despite more than two decades of research and development on nucleic acid vaccines, there is still no commercial product for human use. Taking advantage of the recent innovations in systemic delivery of short interfering RNA (siRNA) using lipid nanoparticles (LNPs), we developed a self-amplifying RNA vaccine.
Andrew J, Geall, Ayush, Verma, Gillis R, Otten, Christine A, Shaw, Armin, Hekele, Kaustuv, Banerjee, Yen, Cu, Clayton W, Beard, Luis A, Brito, Thomas, Krucker, Derek T, O'Hagan, Manmohan, Singh, Peter W, Mason, Nicholas M, Valiante, Philip R, Dormitzer, Susan W, Barnett, Rino, Rappuoli, Jeffrey B, Ulmer, Christian W, Mandl   +18 more
openaire   +2 more sources

A Phase I/II Clinical Trial of Intradermal, Controllable Self-Replicating Ribonucleic Acid Vaccine EXG-5003 against SARS-CoV-2

Vaccines, 2023
mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have played a key role in reducing morbidity and mortality from coronavirus disease 2019 (COVID-19).
Takenao Koseki, Mayumi Teramachi, Minako Koga, Minoru S. H. Ko, Tomokazu Amano, Hong Yu, Misa Amano, Erica Leyder, Maria Badiola, Priyanka Ray, Jiyoung Kim, Akihiro C. Ko, Achouak Achour, Nan-ping Weng, Takumi Imai, Hisako Yoshida, Satsuki Taniuchi, Ayumi Shintani, Hidetsugu Fujigaki, Masashi Kondo, Yohei Doi   +20 more
doaj   +1 more source

The next generation of RNA vaccines: self-amplifying RNA [PDF]

The Biochemist, 2021
The global COVID-19 pandemic has brought tremendous momentum to the field of messenger RNA (mRNA) vaccines. The advantages of this vaccine platform, such as rapid development and high efficacy, resulted in mRNA vaccines being the first approved vaccines against COVID-19.
openaire   +1 more source

Cholesterol-Amino-Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self-Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice. [PDF]

Adv Sci (Weinh), 2023
Du S, Li W, Zhang Y, Xue Y, Hou X, Yan J, Cheng J, Deng B, McComb DW, Lin J, Zeng H, Cheng X, Irvine DJ, Weiss R, Dong Y.   +14 more
europepmc   +2 more sources

Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency. [PDF]

Nat Biotechnol
McGee JE, Kirsch JR, Kenney D, Cerbo F, Chavez EC, Shih TY, Douam F, Wong WW, Grinstaff MW.   +8 more
europepmc   +2 more sources

Real-time kinetics and high-resolution melt curves in single-molecule digital LAMP to differentiate and study specific and non-specific amplification [PDF]

, 2020
Isothermal amplification assays, such as loop-mediated isothermal amplification (LAMP), show great utility for the development of rapid diagnostics for infectious diseases because they have high sensitivity, pathogen-specificity and potential for ...
Barlow, Jacob T., Ismagilov, Rustem F., Jue, Erik, Rolando, Justin C.   +3 more
core   +2 more sources

Design-of-experiments in vitro transcription yield optimization of self-amplifying RNA [PDF]

F1000Research, 2021
Background: Self-amplifying RNA (saRNA) vaccines are able to induce a higher antigen-specific immune response with a more cost-effective and rapid production process compared to plasmid DNA vaccines. saRNAs are synthesized through in vitro transcription (IVT); however ...
Karnyart Samnuan, Anna K. Blakney, Paul F. McKay, Robin J. Shattock   +3 more
openaire   +3 more sources

COVAC1 phase 2a expanded safety and immunogenicity study of a self-amplifying RNA vaccine against SARS-CoV-2. [PDF]

EClinicalMedicine, 2023
Szubert AJ, Pollock KM, Cheeseman HM, Alagaratnam J, Bern H, Bird O, Boffito M, Byrne R, Cole T, Cosgrove CA, Faust SN, Fidler S, Galiza E, Hassanin H, Kalyan M, Libri V, McFarlane LR, Milinkovic A, O'Hara J, Owen DR, Owens D, Pacurar M, Rampling T, Skene S, Winston A, Woolley J, Yim YTN, Dunn DT, McCormack S, Shattock RJ, COVAC 1 Study Team.   +30 more
europepmc   +2 more sources

Can self-amplifying RNA vaccines and viruses exchange genetic material? [PDF]

Mol Ther
Casmil IC, Blakney AK.
europepmc   +3 more sources

Epithelial cell–derived secreted and transmembrane 1a signals to activated neutrophils during pneumococcal pneumonia [PDF]

, 2016
Airway epithelial cell responses are critical to the outcome of lung infection. In this study, we aimed to identify unique contributions of epithelial cells during lung infection.
Belkina, Anna C., Deng, Jane C., Gower, Adam C., Jones, Matthew R., Kamata, Hirofumi, Lung, Wing Yi, Mizgerd, Joseph P., Quinton, Lee J., Ramirez, Maria I., Wasserman, Gregory A., Yamamoto, Kazuko, Yuen, Constance K., Zabinski, Mary C.   +12 more
core   +1 more source