Results 51 to 60 of about 28,679 (139)

Neutral Lipopolyplexes for In Vivo Delivery of Conventional and Replicative RNA Vaccine

Molecular Therapy: Nucleic Acids, 2019
Nucleic acid vaccination relies on injecting DNA or RNA coding antigen(s) to induce a protective immune response. RNA vaccination is being increasingly used in preclinical and clinical studies. However, few delivery systems have been reported for in vivo
Federico Perche, Rudy Clemençon, Kai Schulze, Thomas Ebensen, Carlos A. Guzmán, Chantal Pichon   +5 more
doaj   +1 more source

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science
Messenger RNA (mRNA) has emerged as a versatile platform for gene expression and therapeutic innovation. Early engineering efforts focused on optimizing canonical mRNA components—the 5′ cap, untranslated regions, coding sequence, and poly(A) tail—to ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
doaj   +1 more source

DNA and RNA Vaccines: Current Status, Quality Requirements and Specific Aspects of Preclinical Studies

Биопрепараты: Профилактика, диагностика, лечение, 2019
This review focuses on DNA and RNA vaccines whose potential use was first considered at the end of the 20th century. However, not a single bacterial plasmid-based or mRNA vaccine has been used since that time in public healthcare for the prevention of ...
A. A. Goryaev, M. V. Savkina, Yu. I. Obukhov, V. A. Merkulov, Yu. V. Olefir   +4 more
doaj   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration
Messenger RNA (mRNA) technology is revolutionizing the pharmaceutical industry owing to its superior safety profile, manufacturing capabilities, and potential applications in previously undruggable therapeutic targets. In addition to linear mRNA, such as
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
doaj   +1 more source

The Potential of Self-amplifying RNA Vaccines for Infectious Diseases and COVID-19

Vaccine Research, 2020
In addition to conventional vaccine development for infectious diseases, nucleic acid-based vaccine approaches have recently been presented as serious alternatives to previously used strategies based on live attenuated virus particles and subunit ...
Kenneth Lundstrom
doaj  

Self-Replicating RNA Viruses for RNA Therapeutics

Molecules, 2018
Self-replicating single-stranded RNA viruses such as alphaviruses, flaviviruses, measles viruses, and rhabdoviruses provide efficient delivery and high-level expression of therapeutic genes due to their high capacity of RNA replication.
Kenneth Lundstrom
doaj   +1 more source

Advances and applications of RNA vaccines in tumor treatment

Molecular Cancer
Compared to other types of tumor vaccines, RNA vaccines have emerged as promising alternatives to conventional vaccine therapy due to their high efficiency, rapid development capability, and potential for low-cost manufacturing and safe drug delivery ...
Ruohan Yang, Jiuwei Cui
doaj   +1 more source

Nanoparticle-based delivery of self-amplifying RNA [PDF]

Gene Therapy, 2020
openaire   +2 more sources

The ability of alphavirus replicases to synthesize non-viral type I interferon-inducing RNAs correlates with viral RNA synthesis and has a diverse impact on virus replication and pathogenicity

Journal of Virology
Alphaviruses have positive-strand RNA genomes that mimic cellular mRNAs, and their translation results in the synthesis of nonstructural (ns) polyprotein, the precursor of viral replicase.
Ailar Omler, Anna Rutmane, Suresh Mahalingam, Andres Merits   +3 more
doaj   +1 more source

Alphavirus replicase and regulatory RNA elements in host interactions and viral vector engineering

Journal of Virology
Alphavirus-derived vector systems have been used for heterologous gene expression for nearly four decades, providing foundational insights into RNA virus replication, host interactions, and genome engineering.
Dan T. Boghici, Danni Yong, Silvia M. Vidal, GuanQun Liu   +3 more
doaj   +1 more source