Results 51 to 60 of about 57,349 (269)

Escherichia coli induces apoptosis and proliferation of mammary cells [PDF]

, 2001
Mammary cell apoptosis and proliferation were assessed after injection of Escherichia coli into the left mammary quarters of six cows. Bacteriological analysis of foremilk samples revealed coliform infection in the injected quarters of four cows.
AD Metcalfe, AJ Bramley, AV Capuco, AV Capuco, AW Hill, AW Hill, B Zavizion, BR Rueda, C Kampf, C Legrand, CA Wesson, CB Thompson, CM Alexander, CR Roh, DA Siwik, DE Shuster, DE Shuster, GM Swank, GR Merlo, H Heermeier, JM Adams, JS Hogan, K Schorr, K Schorr, KB Reddy, KR Matthews, KW Bayles, LA Rudolph-Owen, LG Sheffield, LR Lund, M Colitti, M Li, M Li, ME Burow, MM Keane, N Boudjellab, N Boudreau, NA Thornberry, NR Keller, P Maloof, PA Furth, R Blowey, R Strange, RB Hazan, RJ Eberhart, RJ Eberhart, S Ohta, S Pullan, T Tanaka, UK Mebmer, VC Farr, X Li, YJ Tzeng   +52 more
core   +2 more sources

Nuclear β-arrestin1 is a critical cofactor of hypoxia-inducible factor-1α signaling in endothelin-1-induced ovarian tumor progression [PDF]

, 2016
Hypoxia-inducible factor-1α (HIF-1α) mediates the response to hypoxia or other stimuli, such as growth factors, including endothelin-1 (ET-1), to promote malignant progression in numerous tumors.
Bagnato, Anna, Caprara, Valentina, CIANFROCCA, Roberta, Di Castro, Valeriana, Rosanò, Laura, Sestito, Rosanna, TOCCI, PIERA   +6 more
core   +1 more source

Development of a potent Zika virus vaccine using self-amplifying messenger RNA [PDF]

Science Advances, 2020
A Zika self-amplifying mRNA vaccine delivered by a flexible bedside mixing formulation induces protective immunity in NHPs.
Kate Luisi, Kaitlyn M. Morabito, Katherine E. Burgomaster, Mayuri Sharma, Wing-Pui Kong, Bryant M. Foreman, Sonal Patel, Brian Fisher, Maya A. Aleshnick, Jason Laliberte, Madison Wallace, Tracy J. Ruckwardt, David N. Gordon, Christine Linton, Nicole Ruggiero, Jessica L. Cohen, Russell Johnson, Kunal Aggarwal, Sung-Youl Ko, Eun Sung Yang, Rebecca S. Pelc, Kimberly A. Dowd, Derek O’Hagan, Jeffrey Ulmer, Sally Mossman, Anna Sambor, Edith Lepine, John R. Mascola, Theodore C. Pierson, Barney S. Graham, Dong Yu   +30 more
openaire   +2 more sources

Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice

Nature Communications, 2021
Heterologous vaccination regimens for COVID-19 could be useful for example if there is a shortage of one vaccine type. Here, Spencer et al. show that heterologous vaccination with a self-amplifying RNA vaccine and an adenoviral vectored vaccine performs ...
Alexandra J. Spencer, Paul F. McKay, Sandra Belij-Rammerstorfer, Marta Ulaszewska, Cameron D. Bissett, Kai Hu, Karnyart Samnuan, Anna K. Blakney, Daniel Wright, Hannah R. Sharpe, Ciaran Gilbride, Adam Truby, Elizabeth R. Allen, Sarah C. Gilbert, Robin J. Shattock, Teresa Lambe   +15 more
doaj   +1 more source

Self-Replicating RNA Viruses for Vaccine Development against Infectious Diseases and Cancer

Vaccines, 2021
Alphaviruses, flaviviruses, measles viruses and rhabdoviruses are enveloped single-stranded RNA viruses, which have been engineered for recombinant protein expression and vaccine development.
Kenneth Lundstrom
doaj   +1 more source

Efficient Protein Expression and Virus-Induced Gene Silencing in Plants Using a Crinivirus-Derived Vector. [PDF]

, 2018
Plant virus-based vectors are valuable tools for recombinant gene expression and functional genomics for both basic and applied research. In this study, Lettuce infectious yellows virus (LIYV) of the genus Crinivirus was engineered into a virus vector ...
Falk, Bryce W, Qiao, Wenjie
core   +3 more sources

A new generation of vaccines based on alphavirus self-amplifying RNA

Current Opinion in Virology, 2020
DNA or mRNA vaccines have potential advantages over conventional vaccines since they are easier to manufacture and have higher safety profiles. In particular, self-amplifying RNA (saRNA) derived from alphavirus expression vectors has shown to be very efficient to induce humoral and cellular responses against many antigens in preclinical models, being ...
Ballesteros-Briones, María Cristina, Silva-Pilipich, Noelia, Herrador-Cañete, Guillermo, Vanrell, Lucia, Smerdou, Cristian   +4 more
openaire   +2 more sources

Trans-Amplifying RNA: A Journey from Alphavirus Research to Future Vaccines

Viruses
Replicating RNA, including self-amplifying RNA (saRNA) and trans-amplifying RNA (taRNA), holds great potential for advancing the next generation of RNA-based vaccines.
Ayşegül Yıldız, Cristian Răileanu, Tim Beissert   +2 more
doaj   +1 more source

Phytochrome activates the plastid-encoded RNA polymerase for chloroplast biogenesis via nucleus-to-plastid signaling. [PDF]

, 2019
Light initiates chloroplast biogenesis by activating photosynthesis-associated genes encoded by not only the nuclear but also the plastidial genome, but how photoreceptors control plastidial gene expression remains enigmatic.
Blaha, Gregor M, Cao, Jun, Chen, Meng, Pasoreck, Elise K, Wang, He, Weigel, Detlef, Yoo, Chan Yul   +6 more
core   +2 more sources

Enhanced Delivery and Potency of Self-Amplifying mRNA Vaccines by Electroporation in Situ

Vaccines, 2013
Nucleic acid-based vaccines such as viral vectors, plasmid DNA (pDNA), and mRNA are being developed as a means to address limitations of both live-attenuated and subunit vaccines.
Kaustuv Banerjee, Julie Hickman, Andrew Geall, Jeffrey B. Ulmer, Gleb Kichaev, Niranjan Y. Sardesai, Yen Cu, Susan Barnett, Gillis Otten, Kate E. Broderick   +9 more
doaj   +1 more source