Results 41 to 50 of about 28,722 (228)

Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses

Vaccines, 2023
Although conventional vaccine approaches have proven to be successful in preventing infectious diseases in past decades, for vaccine development against emerging/re-emerging viruses, one of the main challenges is rapid response in terms of design and ...
Yalan Liu, Yuncheng Li, Qinxue Hu
doaj   +1 more source

Perspectives on RNA Vaccine Candidates for COVID-19

Frontiers in Molecular Biosciences, 2021
With the current outbreak caused by SARS-CoV-2, vaccination is acclaimed as a public health care priority. Rapid genetic sequencing of SARS-CoV-2 has triggered the scientific community to search for effective vaccines.
Pobitra Borah, Pobitra Borah, Pran Kishore Deb, Nizar A. Al-Shar’i, Lina A. Dahabiyeh, Katharigatta N. Venugopala, Katharigatta N. Venugopala, Vinayak Singh, Vinayak Singh, Pottathil Shinu, Snawar Hussain, Satyendra Deka, Balakumar Chandrasekaran, Da’san M. M. Jaradat   +13 more
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A new generation of vaccines based on alphavirus self-amplifying RNA

Current Opinion in Virology, 2020
DNA or mRNA vaccines have potential advantages over conventional vaccines since they are easier to manufacture and have higher safety profiles. In particular, self-amplifying RNA (saRNA) derived from alphavirus expression vectors has shown to be very efficient to induce humoral and cellular responses against many antigens in preclinical models, being ...
Ballesteros-Briones, María Cristina, Silva-Pilipich, Noelia, Herrador-Cañete, Guillermo, Vanrell, Lucia, Smerdou, Cristian   +4 more
openaire   +2 more sources

The Potential of Extracellular Vesicle-Mediated Spread of Self-Amplifying RNA and a Way to Mitigate It. [PDF]

Int J Mol Sci
Self-amplifying RNA-based (saRNA) technology represents the last frontier in using synthetic RNA in vaccinology. Typically, saRNA consists of positive-strand RNA molecules of viral origin (almost exclusively from alphaviruses) where the sequences of structural proteins are replaced with the open reading frame coding the antigen of interest. For in vivo
Federico M.
europepmc   +3 more sources

Expression Kinetics and Innate Immune Response after Electroporation and LNP-Mediated Delivery of a Self-Amplifying mRNA in the Skin

Molecular Therapy: Nucleic Acids, 2019
In this work, we studied the expression kinetics and innate immune response of a self-amplifying mRNA (sa-RNA) after electroporation and lipid-nanoparticle (LNP)-mediated delivery in the skin of mice. Intradermal electroporation of the sa-RNA resulted in
Hanne Huysmans, Zifu Zhong, Joyca De Temmerman, Barbara L. Mui, Ying K. Tam, Séan Mc Cafferty, Arlieke Gitsels, Daisy Vanrompay, Niek N. Sanders   +8 more
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Self-Replicating RNA Viruses for Vaccine Development against Infectious Diseases and Cancer

Vaccines, 2021
Alphaviruses, flaviviruses, measles viruses and rhabdoviruses are enveloped single-stranded RNA viruses, which have been engineered for recombinant protein expression and vaccine development.
Kenneth Lundstrom
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Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice

Nature Communications, 2021
Heterologous vaccination regimens for COVID-19 could be useful for example if there is a shortage of one vaccine type. Here, Spencer et al. show that heterologous vaccination with a self-amplifying RNA vaccine and an adenoviral vectored vaccine performs ...
Alexandra J. Spencer, Paul F. McKay, Sandra Belij-Rammerstorfer, Marta Ulaszewska, Cameron D. Bissett, Kai Hu, Karnyart Samnuan, Anna K. Blakney, Daniel Wright, Hannah R. Sharpe, Ciaran Gilbride, Adam Truby, Elizabeth R. Allen, Sarah C. Gilbert, Robin J. Shattock, Teresa Lambe   +15 more
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Trans-Amplifying RNA: A Journey from Alphavirus Research to Future Vaccines

Viruses
Replicating RNA, including self-amplifying RNA (saRNA) and trans-amplifying RNA (taRNA), holds great potential for advancing the next generation of RNA-based vaccines.
Ayşegül Yıldız, Cristian Răileanu, Tim Beissert   +2 more
doaj   +1 more source

Development of a potent Zika virus vaccine using self-amplifying messenger RNA [PDF]

Science Advances, 2020
A Zika self-amplifying mRNA vaccine delivered by a flexible bedside mixing formulation induces protective immunity in NHPs.
Kate Luisi, Kaitlyn M. Morabito, Katherine E. Burgomaster, Mayuri Sharma, Wing-Pui Kong, Bryant M. Foreman, Sonal Patel, Brian Fisher, Maya A. Aleshnick, Jason Laliberte, Madison Wallace, Tracy J. Ruckwardt, David N. Gordon, Christine Linton, Nicole Ruggiero, Jessica L. Cohen, Russell Johnson, Kunal Aggarwal, Sung-Youl Ko, Eun Sung Yang, Rebecca S. Pelc, Kimberly A. Dowd, Derek O’Hagan, Jeffrey Ulmer, Sally Mossman, Anna Sambor, Edith Lepine, John R. Mascola, Theodore C. Pierson, Barney S. Graham, Dong Yu   +30 more
openaire   +2 more sources

Enhanced Delivery and Potency of Self-Amplifying mRNA Vaccines by Electroporation in Situ

Vaccines, 2013
Nucleic acid-based vaccines such as viral vectors, plasmid DNA (pDNA), and mRNA are being developed as a means to address limitations of both live-attenuated and subunit vaccines.
Kaustuv Banerjee, Julie Hickman, Andrew Geall, Jeffrey B. Ulmer, Gleb Kichaev, Niranjan Y. Sardesai, Yen Cu, Susan Barnett, Gillis Otten, Kate E. Broderick   +9 more
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