Results 21 to 30 of about 28,722 (228)

Progress in researches on self-amplifying RNA vaccines

Zhongguo gonggong weisheng, 2023
Self-amplifying RNA (saRNA) vaccines are a new generation of mRNA vaccines. In addition to containing mRNA sequences encoding antigen proteins, saRNA vaccines also have unique self-amplifying elements, so self-amplification of antigen sequences can be ...
Shuo WANG, Jianmin LI
doaj   +2 more sources

Self-amplifying RNA (saRNA) and circular RNA (circRNA) vaccines: Progress, evidence gaps, and translational pathways for durable and scalable immunization [PDF]

Human Vaccines & Immunotherapeutics
Self-amplifying RNA (saRNA) and circular RNA (circRNA) are emerging vaccine modalities that extend conventional, non-replicating mRNA platforms. Self-amplifying RNA encodes a replicase that amplifies intracellular RNA templates, enabling high antigen ...
Ugwu Okechukwu Paul-Chima, Okon Michael Ben, Ogenyi Fabian C., Ugwu Jovita Nnenna, Ugwu Chinyere N.   +4 more
doaj   +2 more sources

A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability [PDF]

npj Vaccines, 2022
mRNA vaccines were the first to be authorized for use against SARS-CoV-2 and have since demonstrated high efficacy against serious illness and death. However, limitations in these vaccines have been recognized due to their requirement for cold storage ...
Emily A. Voigt, Alana Gerhardt, Derek Hanson, Madeleine F. Jennewein, Peter Battisti, Sierra Reed, Jasneet Singh, Raodoh Mohamath, Julie Bakken, Samuel Beaver, Christopher Press, Patrick Soon-Shiong, Christopher J. Paddon, Christopher B. Fox, Corey Casper   +14 more
doaj   +3 more sources

Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles [PDF]

Vaccines, 2014
Dendritic cells (DC) play essential roles determining efficacy of vaccine delivery with respect to immune defence development and regulation. This renders DCs important targets for vaccine delivery, particularly RNA vaccines.
Kenneth C. McCullough, Panagiota Milona, Lisa Thomann-Harwood, Thomas Démoulins, Pavlos Englezou, Rolf Suter, Nicolas Ruggli   +6 more
doaj   +3 more sources

A sort and sequence approach to dissect heterogeneity of response to a self-amplifying RNA vector in a novel human muscle cell line [PDF]

Molecular Therapy: Nucleic Acids
Self-amplifying RNA (saRNA) is an extremely promising platform because it can produce more protein for less RNA. We used a sort and sequence approach to identify host cell factors associated with transgene expression from saRNA; the hypothesis was that ...
Rachel D. Barton, John S. Tregoning, Ziyin Wang, Daniel Gonçalves-Carneiro, Radhika Patel, Paul F. McKay, Robin J. Shattock   +6 more
doaj   +2 more sources

Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport [PDF]

npj Vaccines
Self-amplifying RNA (saRNA)-based vaccines have emerged as a potent and durable RNA vaccine platform relative to first generation mRNA vaccines. However, RNA vaccine platforms trigger undesirable side effects at protective doses, underscoring the need ...
Jason A. Wojcechowskyj, Robyn M. Jong, Imre Mäger, Britta Flach, Paul V. Munson, Progya P. Mukherjee, Barbara Mertins, Katherine R. Barcay, Thomas Folliard   +8 more
doaj   +2 more sources

Self-Amplifying RNA Approach for Protein Replacement Therapy. [PDF]

Int J Mol Sci, 2022
Messenger RNA (mRNA) technology has already been successfully tested preclinically and there are ongoing clinical trials for protein replacement purposes; however, more effort has been put into the development of prevention strategies against infectious diseases.
Papukashvili D, Rcheulishvili N, Liu C, Ji Y, He Y, Wang PG.   +5 more
europepmc   +3 more sources

Reinventing the nucleic acid vaccine with self-amplifying RNA [PDF]

Retrovirology, 2012
Background Self-amplifying RNAs (replicons) of positive-strand viruses such as alphaviruses are potentially safe and useful vectors for delivering vaccine antigens. We previously showed that recombinant alphavirus replicon particles (VRP), used in prime-boost regimen with Env in MF59 protein protected rhesus macaques against mucosal challenge with ...
Geall AJ, Otten GR, Hekele A, Bogers W, Oostermeijer H, Mooij P, Gerrit K, Verschoor E, Banerjee K, Cu Y, Beard CW, Brito LA, Ulmer JB, Mandl CW, Barnett SW   +14 more
doaj   +2 more sources

Self-amplifying RNA vaccines for infectious diseases [PDF]

Gene Therapy, 2020
Vaccinology is shifting toward synthetic RNA platforms which allow for rapid, scalable, and cell-free manufacturing of prophylactic and therapeutic vaccines. The simple development pipeline is based on in vitro transcription of antigen-encoding sequences or immunotherapies as synthetic RNA transcripts, which are then formulated for delivery.
Bloom, Kristie, van den Berg, Fiona, Arbuthnot, Patrick   +2 more
openaire   +2 more sources

In Vitro Transcribed RNA-Based Platform Vaccines: Past, Present, and Future

Vaccines, 2023
mRNA was discovered in 1961, but it was not used as a vaccine until after three decades. Recently, the development of mRNA vaccine technology gained great impetus from the pursuit of vaccines against COVID-19.
Alexey D. Perenkov, Alena D. Sergeeva, Maria V. Vedunova, Dmitri V. Krysko   +3 more
doaj   +1 more source