Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles [PDF]
Vaccines, 2014 Dendritic cells (DC) play essential roles determining efficacy of vaccine delivery with respect to immune defence development and regulation. This renders DCs important targets for vaccine delivery, particularly RNA vaccines.
Kenneth C. McCullough +6 more
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Trans-Amplifying RNA: A Journey from Alphavirus Research to Future Vaccines
VirusesReplicating RNA, including self-amplifying RNA (saRNA) and trans-amplifying RNA (taRNA), holds great potential for advancing the next generation of RNA-based vaccines.
Ayşegül Yıldız +2 more
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A sort and sequence approach to dissect heterogeneity of response to a self-amplifying RNA vector in a novel human muscle cell line [PDF]
Molecular Therapy: Nucleic AcidsSelf-amplifying RNA (saRNA) is an extremely promising platform because it can produce more protein for less RNA. We used a sort and sequence approach to identify host cell factors associated with transgene expression from saRNA; the hypothesis was that ...
Rachel D. Barton +6 more
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Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines
Vaccines, 2020 messenger RNA (mRNA)-based vaccines combine the positive attributes of both live-attenuated and subunit vaccines. In order for these to be applied for clinical use, they require to be formulated with delivery systems.
Giulia Anderluzzi +7 more
doaj +3 more sources
Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport [PDF]
npj VaccinesSelf-amplifying RNA (saRNA)-based vaccines have emerged as a potent and durable RNA vaccine platform relative to first generation mRNA vaccines. However, RNA vaccine platforms trigger undesirable side effects at protective doses, underscoring the need ...
Jason A. Wojcechowskyj +8 more
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The advent of clinical self-amplifying RNA vaccines. [PDF]
Mol TherCasmil IC +6 more
europepmc +2 more sources
In Vitro Transcribed RNA-Based Platform Vaccines: Past, Present, and Future
Vaccines, 2023 mRNA was discovered in 1961, but it was not used as a vaccine until after three decades. Recently, the development of mRNA vaccine technology gained great impetus from the pursuit of vaccines against COVID-19.
Alexey D. Perenkov +3 more
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Progress in researches on self-amplifying RNA vaccines
Zhongguo gonggong weisheng, 2023 Self-amplifying RNA (saRNA) vaccines are a new generation of mRNA vaccines. In addition to containing mRNA sequences encoding antigen proteins, saRNA vaccines also have unique self-amplifying elements, so self-amplification of antigen sequences can be ...
Shuo WANG, Jianmin LI
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RNA Combined with Nanoformulation to Advance Therapeutic Technologies
Pharmaceuticals, 2023 Nucleic acid-based therapies have the potential to address numerous diseases that pose significant challenges to more traditional methods. RNA-based therapies have emerged as a promising avenue, utilizing nanoformulation treatments to target a range of ...
Eduarda Santos Lima +11 more
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An Update on Self-Amplifying mRNA Vaccine Development
Vaccines, 2021 This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)).
Anna K. Blakney +2 more
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