The advent of clinical self-amplifying RNA vaccines [PDF]
Molecular TherapySelf-amplifying RNA (saRNA) technology is an emerging platform for vaccine development, offering significant advantages over conventional mRNA vaccines. By enabling intracellular amplification of RNA, saRNA facilitates robust antigen expression at lower doses, thereby enhancing both immunogenicity and cost-effectiveness. This review examines the latest
Anna Blakney +2 more
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Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines [PDF]
Vaccines, 2020 messenger RNA (mRNA)-based vaccines combine the positive attributes of both live-attenuated and subunit vaccines. In order for these to be applied for clinical use, they require to be formulated with delivery systems.
Gustavo Lou +2 more
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Progress in researches on self-amplifying RNA vaccines
Zhongguo gonggong weisheng, 2023 Self-amplifying RNA (saRNA) vaccines are a new generation of mRNA vaccines. In addition to containing mRNA sequences encoding antigen proteins, saRNA vaccines also have unique self-amplifying elements, so self-amplification of antigen sequences can be ...
Shuo WANG, Jianmin LI
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A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability. [PDF]
NPJ Vaccines, 2022 mRNA vaccines were the first to be authorized for use against SARS-CoV-2 and have since demonstrated high efficacy against serious illness and death. However, limitations in these vaccines have been recognized due to their requirement for cold storage ...
Voigt EA +14 more
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Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles
International Journal of Nanomedicine, 2014 Alicia Rodríguez-Gascón, Ana del Pozo-Rodríguez, María Ángeles SolinísPharmacokinetic, Nanotechnology and Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, Centro de Investigación Lascaray ...
Maria Angeles Solinís +2 more
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A sort and sequence approach to dissect heterogeneity of response to a self-amplifying RNA vector in a novel human muscle cell line. [PDF]
Mol Ther Nucleic AcidsSelf-amplifying RNA (saRNA) is an extremely promising platform because it can produce more protein for less RNA. We used a sort and sequence approach to identify host cell factors associated with transgene expression from saRNA; the hypothesis was that ...
Barton RD +6 more
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Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport. [PDF]
NPJ VaccinesSelf-amplifying RNA (saRNA)-based vaccines have emerged as a potent and durable RNA vaccine platform relative to first generation mRNA vaccines. However, RNA vaccine platforms trigger undesirable side effects at protective doses, underscoring the need ...
Wojcechowskyj JA +8 more
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Self-Amplifying RNA Approach for Protein Replacement Therapy. [PDF]
Int J Mol Sci, 2022 Messenger RNA (mRNA) technology has already been successfully tested preclinically and there are ongoing clinical trials for protein replacement purposes; however, more effort has been put into the development of prevention strategies against infectious diseases.
Papukashvili D +5 more
europepmc +3 more sources
In Vitro Transcribed RNA-Based Platform Vaccines: Past, Present, and Future
Vaccines, 2023 mRNA was discovered in 1961, but it was not used as a vaccine until after three decades. Recently, the development of mRNA vaccine technology gained great impetus from the pursuit of vaccines against COVID-19.
Alexey D. Perenkov +3 more
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RNA Combined with Nanoformulation to Advance Therapeutic Technologies
Pharmaceuticals, 2023 Nucleic acid-based therapies have the potential to address numerous diseases that pose significant challenges to more traditional methods. RNA-based therapies have emerged as a promising avenue, utilizing nanoformulation treatments to target a range of ...
Eduarda Santos Lima +11 more
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