Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development [PDF]
Pathogens, 2023 The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA ...
Christin Schmidt, Barbara S. Schnierle
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Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines [PDF]
Molecular Therapy: Nucleic Acids, 2023 To be effective, RNA vaccines require both in situ translation and the induction of an immune response to recruit cells to the site of immunization. These factors can pull in opposite directions with the inflammation reducing expression of the vaccine ...
John S. Tregoning +13 more
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A bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses [PDF]
Frontiers in ImmunologyIntroductionYellow fever (YFV) and Zika (ZIKV) viruses cause significant morbidity and mortality, despite the existence of an approved YFV vaccine and the development of multiple ZIKV vaccine candidates to date.
Peter Battisti +19 more
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Self-Amplifying RNA: Advantages and Challenges of a Versatile Platform for Vaccine Development [PDF]
VirusesSelf-amplifying RNA is synthetic nucleic acid engineered to replicate within cells without generating viral particles. Derived from alphavirus genomes, saRNA retains the non-structural elements essential for replication while replacing the structural ...
Thomas Vallet, Marco Vignuzzi
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A self-amplifying RNA vaccine provides protection in a murine model of bubonic plague [PDF]
Frontiers in Microbiology, 2023 Mice were immunized with a combination of self-amplifying (sa) RNA constructs for the F1 and V antigens of Yersinia pestis at a dose level of 1 μg or 5 μg or with the respective protein sub-units as a reference vaccine.
Robin John Shattock +11 more
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Self-Amplifying Replicon RNA Delivery to Dendritic Cells by Cationic Lipids [PDF]
Molecular Therapy: Nucleic Acids, 2018 Advances in RNA technology during the past two decades have led to the construction of replication-competent RNA, termed replicons, RepRNA, or self-amplifying mRNA, with high potential for vaccine applications.
Pavlos C. Englezou +10 more
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Self-Amplifying RNA: A Second Revolution of mRNA Vaccines against COVID-19 [PDF]
VaccinesSARS-CoV-2 virus, the causative agent of COVID-19, has produced the largest pandemic in the 21st century, becoming a very serious health problem worldwide.
Noelia Silva-Pilipich +3 more
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The advent of clinical self-amplifying RNA vaccines [PDF]
Molecular TherapySelf-amplifying RNA (saRNA) technology is an emerging platform for vaccine development, offering significant advantages over conventional mRNA vaccines. By enabling intracellular amplification of RNA, saRNA facilitates robust antigen expression at lower doses, thereby enhancing both immunogenicity and cost-effectiveness. This review examines the latest
Irafasha C Casmil +2 more
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Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles
International Journal of Nanomedicine, 2014 Alicia Rodríguez-Gascón, Ana del Pozo-Rodríguez, María Ángeles SolinísPharmacokinetic, Nanotechnology and Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, Centro de Investigación Lascaray ...
Rodríguez-Gascón A +2 more
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Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines [PDF]
Vaccines, 2020 messenger RNA (mRNA)-based vaccines combine the positive attributes of both live-attenuated and subunit vaccines. In order for these to be applied for clinical use, they require to be formulated with delivery systems.
Giulia Anderluzzi +7 more
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