Results 61 to 70 of about 28,679 (139)

Deciphering the Nodamura virus Protein A Function in Schizosaccharomyces pombe and Engineering a Novel Self-Amplifying RNA (saRNA) Vector NovaVec for Vaccine Development

Vaccines
Background/Objectives: Self-amplifying RNA (saRNA) vectors enable high-level transgene expression from minimal initial doses. While alphavirus-based saRNA systems are widely used, they suffer from limitations, including large genome size, complex ...
Xueyao Song, Ruihan Liu, Zhuo Zhang, Yuying Pan, Wanting Qu, Niubing Zhang, Xuan Li, Xiangping Yao, Pei Hao   +8 more
doaj   +1 more source

Negative-sense RNA virus nucleocapsid as a versatile platform for gene delivery, vaccine development, and antiviral screening

Scientific Reports
Viruses typically infiltrate host cells via specialized cellular receptors, a pivotal step that is challenging when suitable permissive cell lines or hosts are unavailable.
Sheeba Rehman, Pruthviraj M. Chavan, Akanksha Chaturvedi, Debasis Nayak   +3 more
doaj   +1 more source

A self-amplifying RNA vector based on rubella virus for mRNA therapeutics and vaccine applications. [PDF]

Mol Ther Nucleic Acids
Jing M, Law MCY, Phung CD, He Y, Tan YB, Le MTN, Luo D.   +6 more
europepmc   +1 more source

A duplex droplet digital PCR assay for absolute quantification and characterization of long self-amplifying RNA. [PDF]

Sci Rep, 2023
Casmil IC, Huang C, Blakney AK.
europepmc   +1 more source

A Self-Amplifying RNA Lipid Nanoparticle (saRNA-LNP) Vaccine Provides Effective Protection Against Porcine Epidemic Diarrhea. [PDF]

Transbound Emerg Dis
Shu J, Zhang H, Wang F, Zhang H, Liu X, Liu K, Zha Y, Chai W, Yao J, Lin Y, Wu C, Zhao X.   +11 more
europepmc   +1 more source

Single intramuscular injection of self-amplifying RNA of <i>Nppa</i> to treat myocardial infarction. [PDF]

Science
Zhang K, Tao H, Zhu D, Yue Z, Hu S, Wu Y, Yan N, Hu Y, Liu S, Liu M, Vahl TP, Ranard LS, Cheng X, Romanov A, Liu J, Zhang SW, Li Y, Lu C, Shen M, Lewis A, Huang K, Cheng K.   +21 more
europepmc   +1 more source

Enhanced immunogenicity and dose-sparing efficacy of self-amplifying RNA vaccines against seasonal influenza across subtypes. [PDF]

Emerg Microbes Infect
Huang M, Quan Y, Chen R, Gu H, Song W, Zhu F, Feng S, Lin J, Lu J, Li X, Li W, Pan Q, Li H, Sun L, Jiang T, Zhang B, Yin X, Wei D, Yang C, Liu D, Wang Z, Jia W, Zhao J, Yu J, Li X, Yu X, Yue X, Li C, Bu F, Miao Z, Zhang Q.   +30 more
europepmc   +1 more source

Optimization of In Vitro Transcription by Design of Experiment to Achieve High Self-Amplifying RNA Integrity. [PDF]

Vaccines (Basel)
Hu C, Wang H, Liu G, Li K, Zhang X, Song L, Gao F, Wu X, Wang Q, Liu M, Liu J, Fu Z, Ma X, Xu M, Mao Q, Liang Z, He Q.   +16 more
europepmc   +1 more source

Identification, design, and <i>in vivo</i> proof of concept of a shared APC neoantigen delivered via a self-amplifying RNA containing virus-like nanoparticle for cancer vaccination. [PDF]

Front Immunol
Simmons AJ, Nikonova AS, Jonas CD, Pniewski KA, Upreti D, Perez MI, Adhikari S.   +6 more
europepmc   +1 more source

Biophysical characterization of the structure of a SARS-CoV-2 self-amplifying RNA (saRNA) vaccine. [PDF]

Biol Methods Protoc, 2023
Myatt DP, Wharram L, Graham C, Liddell J, Branton H, Pizzey C, Cowieson N, Rambo R, Shattock RJ.   +8 more
europepmc   +1 more source