Results 101 to 110 of about 18,157,587 (245)

SARS-CoV-2 Uzbekistan MetaData

, 2022
Tracking temporal and spatial genomic changes and evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Uzbekistan.
Alisher Abdullaev (12124800)
core   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

SARS-CoV-2 ORF8, rather than SARS-CoV ORF8, has an unconventional secretion pattern.

, 2023
(A) Structures of SARS-CoV-2 ORF8 and its signal peptide-deleted mutant. (B, C) Full-length SARS-CoV-2 ORF8 or its signal peptide-deleted mutant was transfected into Calu-3 cells or HEK-293FT cells. The secretion of ORF8 was detected by western blotting (
Dusan Kunec (4341475), Na Xing (823501), Xiaoyuan Lin (6558212), Dong Guo (442625), Krishna Pavani (14493334), Weiwei Xue (527290), Jakob Trimpert (4341478), Haibo Wu (156272), Yan Xiong (197517), Beibei Fu (8815745), Mohamed Zaky (14493331)   +10 more
core   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

SARS-CoV-2 seropositivity by participant demographics and SARS-CoV-2 exposures and risk behaviors.

SARS-CoV-2 seropositivity by participant demographics and SARS-CoV-2 exposures and risk behaviors.
Sombo Fwoloshi (4321150), Kalubi Kalenga (18297785), Elizabeth Heilmann (18297776), Tannia Tembo (6785636), Mpanji Siwingwa (3690319), Izukanji Sikazwe (531945), Bupe Kabamba (18297779), Felix Chilambe (18297782), Lloyd B. Mulenga (6785501), Ruchi Yadav (189335), Samuel Yingst (30536), Victoria Seffren (18297788), Theodora Savory (5340821), Simon Agolory (847088), Muzala Kapina (18275558), Carolyn Bolton-Moore (428685), Andrew F. Auld (8967719), John Simwanza (18297791), Julie R. Gutman (5108699), Chabu Kangale (15271594), Conceptor Mulube (8309931), Jonas Z. Hines (16520538), Eric Rogier (3433718)   +22 more
core   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

SARS-CoV-2 Cross-reactive T cells.

, 2021
(A) CD154 upregulation assay of potential cross-reactive epitopes. Top panel: DR0101 SARS- CoV-2 S961-980, middle panel: DR1501 SARS-CoV-2 S1001-1020, and bottom panel: DP0401 SARS-CoV-2 S809-828. SARS-CoV-2 peptide-specific cell lines were generated and
Uma Malhotra (847242), Alexandra M. Johansson (11441927), Maxwell P. Krist (11886473), Yeseul G. Kim (11886467), David M. Koelle (8138436), Rebecca Gomez (11886470), William W. Kwok (7380419), Anna Wald (172640)   +7 more
core   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

SARS-CoV-2 Prevalence and Variant Surveillance among Cats in Pittsburgh, Pennsylvania, USA

, 2023
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects many mammals, and SARS-CoV-2 circulation in nonhuman animals may increase the risk of novel variant emergence.
Shubhada K. Chothe, Deepanker Tewari, Becky Morrow, Michele Yon, Ruth H. Nissly, Saranya Amirthalingam, Padmaja Jakka, Sheweta Gupta, Meera Surendran Nair, Abhinay Gontu, Lindsey C. LaBella, Sabarinath Neerukonda, Diana Ruggiero, Joshua T. Lizer, Santhamani Ramasamy, John M. Hardham, Suresh V. Kuchipudi   +16 more
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source