Results 101 to 110 of about 24,947,200 (233)

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

SARS-CoV-2 Cross-reactive T cells.

, 2021
(A) CD154 upregulation assay of potential cross-reactive epitopes. Top panel: DR0101 SARS- CoV-2 S961-980, middle panel: DR1501 SARS-CoV-2 S1001-1020, and bottom panel: DP0401 SARS-CoV-2 S809-828. SARS-CoV-2 peptide-specific cell lines were generated and
Uma Malhotra (847242), Alexandra M. Johansson (11441927), Maxwell P. Krist (11886473), Yeseul G. Kim (11886467), David M. Koelle (8138436), Rebecca Gomez (11886470), William W. Kwok (7380419), Anna Wald (172640)   +7 more
core   +1 more source

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

Advanced Science, EarlyView.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng, Evan M. Cale, Amirabbas Maghsoudi, Matthew S. Sutton, Nancy S. Longo, Rebecca A. Gillespie, Lingshu Wang, Ivan Kosik, Sue Chong, Atsuhiro Yasuhara, Tatsiana Bylund, Arne Schön, Prabhanshu Tripathi, Yaroslav Tsybovsky, Haotian Lei, Nicholas C. Morano, Allison B. Lupatkin, Abraham J. Morton, Zabrina C. Lang, Jordan E. Becker, Isabella R. Frascilla, Myungjin Lee, Ning Li, Cuiping Liu, Ryan S. Roark, Chen‐Hsiang Shen, I‐Ting Teng, David J. Van Wazer, Danyi Wang, Lingyuan Wu, Goran Ahlsen, Mike Castro, Haijuan Du, Michael J. Ernandes, Tiansheng Li, Bob C. Lin, Mark K. Louder, Krisha McKee, Jonah S. Merriam, Sijy O'Dell, Li Ou, Sergei Pletnev, David Prikryl, Qi Qiu, Sarah Rubin, Mallika Sastry, Stephen D. Schmidt, Asif Shajahan, Andrea R. Shiakolas, Sanjay Srivatsan, Baoshan Zhang, Qiong Zhou, Mark Connors, Jason G. Gall, Yicheng Guo, Rick K. Huang, Yaoxing Huang, Richard A. Koup, Q. Paula Lei, John R. Mascola, Reda Rawi, Leonid Serebryannyy, Lawrence Shapiro, Zizhang Sheng, David D. Ho, Patrick C. Wilson, Jonathan W. Yewdell, Theodore C. Pierson, Masaru Kanekiyo, Nicole A. Doria‐Rose, Peter D. Kwong, Tongqing Zhou   +71 more
wiley   +1 more source

Surveillance of seasonal respiratory viruses among Chilean patients during the COVID‐19 pandemic

Health Science Reports, 2021
Luis A. Alonso‐Palomares, C. Joaquín Cáceres, Rodrigo Tapia, Paulina Aguilera‐Cortés, Santiago Valenzuela, Fernando Valiente‐Echeverría, Ricardo Soto‐Rifo, Aldo Gaggero, Gonzalo P. Barriga   +8 more
doaj   +1 more source

SARS-CoV-2 ORF8, rather than SARS-CoV ORF8, has an unconventional secretion pattern.

, 2023
(A) Structures of SARS-CoV-2 ORF8 and its signal peptide-deleted mutant. (B, C) Full-length SARS-CoV-2 ORF8 or its signal peptide-deleted mutant was transfected into Calu-3 cells or HEK-293FT cells. The secretion of ORF8 was detected by western blotting (
Dusan Kunec (4341475), Na Xing (823501), Xiaoyuan Lin (6558212), Dong Guo (442625), Krishna Pavani (14493334), Weiwei Xue (527290), Jakob Trimpert (4341478), Haibo Wu (156272), Yan Xiong (197517), Beibei Fu (8815745), Mohamed Zaky (14493331)   +10 more
core   +1 more source

Reporte nº4 – Provincia de Córdoba –19 de agosto de 2020. Consorcio interinstitucional para la Secuenciación del genoma y estudios genómicos de SARSCOV-2 (Proyecto PAIS) [PDF]

, 2020
Fil: Consorcio Argentino de Genómica de SARS-CoV-2; Argentina.Fil: Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología Dr. José María Vanella; Argentina.Fil: Gobierno de la Provincia de Córdoba.
Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Instituto de Virología Dr. José María Vanella; Argentina, Gobierno de la Provincia de Córdoba. Ministerio de Salud. Laboratorio Central; Argentina, Consorcio Argentino de Genómica de SARS-CoV-2   +2 more
core   +1 more source

From Sensing Mechanisms to System Co‐Design: Graphene‐Based Sensors and Readout Circuits

Advanced Science, EarlyView.
This review establishes a unified PS–EQ–RF framework linking graphene sensing mechanisms, native electrical outputs, and output‐specific readout circuits. Voltage‐, current‐, resistance‐, and capacitance‐type sensing systems are systematically classified to guide architecture selection, low‐noise design, system co‐design, and practical integration ...
Jinduo Zhang, Meng Chen, Guanchen Li, Ruifeng Liu, Yingxin Wang, Ziran Zhao   +5 more
wiley   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

SARS-CoV-2 seropositivity by participant demographics and SARS-CoV-2 exposures and risk behaviors.

SARS-CoV-2 seropositivity by participant demographics and SARS-CoV-2 exposures and risk behaviors.
Sombo Fwoloshi (4321150), Kalubi Kalenga (18297785), Elizabeth Heilmann (18297776), Tannia Tembo (6785636), Mpanji Siwingwa (3690319), Izukanji Sikazwe (531945), Bupe Kabamba (18297779), Felix Chilambe (18297782), Lloyd B. Mulenga (6785501), Ruchi Yadav (189335), Samuel Yingst (30536), Victoria Seffren (18297788), Theodora Savory (5340821), Simon Agolory (847088), Muzala Kapina (18275558), Carolyn Bolton-Moore (428685), Andrew F. Auld (8967719), John Simwanza (18297791), Julie R. Gutman (5108699), Chabu Kangale (15271594), Conceptor Mulube (8309931), Jonas Z. Hines (16520538), Eric Rogier (3433718)   +22 more
core   +1 more source