Results 121 to 130 of about 1,293,835 (325)

SARS-CoV-2 Infection in Children

New England Journal of Medicine, 2020
SARS-CoV-2 Infection in Children In this report, investigators in Wuhan, China, describe the spectrum of Covid-19 illness in children under the age of 16 years.
Xiaoxia Lu, Liqiong Zhang, H. Du, Jingjing Zhang, Yuan Y Li, Jingyu Qu, Wenxin Zhang, Youjie Wang, Shuangshuang Bao, Ying Li, Chuansha Wu, Hongxiu Liu, Di Liu, J. Shao, Xuehua Peng, Yonghong Yang, Zhi-sheng Liu, Yun Xiang, Furong Zhang, Rona M. Silva, K. Pinkerton, K. Shen, Han Xiao, Shunqing Xu, G. Wong   +24 more
semanticscholar   +1 more source

The Appropriate Use of Testing for COVID-19 [PDF]

, 2020
Many public officials are calling for increased testing for the 2019 novel coronavirus disease (COVID-19), and some governments have taken extraordinary measures to increase the availability of testing.
Zitek, Tony
core  

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Infección por SARS-COV-2 en trabajadores de la salud: análisis de riesgo epidemiológico en una institución de alta complejidad de Bogotá, Colombia, 2020

Infectio, 2022
Objective: To determine the incidence of SARS-CoV-2 infection and its association with sociodemographic, clinical, and occupational characteristics in health workers (HCWs) in the COVID-19 risk area.Material and method: Longitudinal analytical study in a
Milcíades Ibáñez-Pinilla
doaj   +1 more source

Cyclophilin A‐mediated mitigation of coronavirus SARS‐CoV‐2

Bioengineering & Translational Medicine, 2023
Human cyclophilin A (hCypA) is important for the replication of multiple coronaviruses (CoVs), and cyclosporine A inhibitors can suppress CoVs. The emergence of rapidly spreading severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants has ...
Simranjeet Singh Sekhon, Woo‐Ri Shin, Sang Yong Kim, Dong‐Seok Jeong, Wooil Choi, Bong‐Keun Choi, Jiho Min, Ji‐Young Ahn, Yang‐Hoon Kim   +8 more
doaj   +1 more source

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

Intensive Care Medicine, 2020
A novel infectious disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in Wuhan, China, in December 2019. The disease (COVID-19) spread rapidly, reaching epidemic proportions in China, and has been found in 27 ...
Haibo Zhang, J. Penninger, Yimin Li, N. Zhong, Arthur S Slutsky   +4 more
semanticscholar   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

Humoral response to SARS-CoV-2 adenovirus vector vaccination (ChAdOx1 nCoV-19 [AZD1222]) in heart transplant recipients aged 18 to 70 years of age [PDF]

, 2022
Richard Tanner, Neasa Starr, Grace Chan, Eimear Dempsey, Emma Heffernan, Ellen Newman, James P. O’Neill, Margaret M. Hannan, Breda Lynch, Emer Joyce   +9 more
openalex   +1 more source

CRISPR-Cas12–based detection of SARS-CoV-2

Nature Biotechnology, 2020
An outbreak of betacoronavirus severe acute respiratory syndrome (SARS)-CoV-2 began in Wuhan, China in December 2019. COVID-19, the disease associated with SARS-CoV-2 infection, rapidly spread to produce a global pandemic.
James P. Broughton, Xianding Deng, Guixia Yu, C. Fasching, V. Servellita, J. Singh, X. Miao, J. Streithorst, A. Granados, A. Sotomayor-González, K. Zorn, Allan Gopez, Elaine D. Hsu, W. Gu, Steve Miller, C. Pan, H. Guevara, D. Wadford, Janice S. Chen, C. Chiu   +19 more
semanticscholar   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source