Results 201 to 210 of about 1,293,835 (325)
Advanced Intelligent Discovery, EarlyView.This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng +4 more
wiley +1 more source
Balancing Fiscal and Mortality Impact of SARS-CoV-2 Mitigation Measurements [PDF]
, 2020 Mayteé Cruz-Aponte +1 more
openalex +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Slimane Allali +14 more
wiley +1 more source
Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen +16 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud +3 more
wiley +1 more source
Annals of Neurology, EarlyView.Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B‐ and T‐cell receptor repertoires and relapse activity were assessed at baseline and after 24 months. T‐cell clonality
Tilman Schneider‐Hohendorf +8 more
wiley +1 more source
SARS-CoV-2 Chronic Intervillositis: Variations of Maternal Antiviral Response. [PDF]
Am J Reprod ImmunolKozlova D +8 more
europepmc +1 more source
Migration and Dispersion Evolution of Exhaled Aerosol in a Ward Under Different Ventilation Modes
Asia-Pacific Journal of Chemical Engineering, EarlyView.ABSTRACT Wards with special functions and closure will have a higher risk of viral transmission as aerosols are an important mode of transmission for the SARS‐CoV‐2 virus. In this study, an experimental platform was built to establish the relevant parameters of the aerosol model and the aerosol propagation model according to the experimental results ...
Jingzhi Zhang +8 more
wiley +1 more source
Antibody responses to SARS-CoV-2 in patients with COVID-19
Nature Medicine, 2020 Quan-xin Long +50 more
semanticscholar +1 more source
Surfactant‐Enhanced Electrospun Nanofiber Filters for Efficient Viral and Bacterial Inactivation
Journal of Applied Polymer Science, EarlyView.In this work, electrospun polyacrylonitrile (PAN) nanofibrous filters functionalized with surfactants (CTAB, CPC, and SDS) were developed for air filtration applications. The PAN nanofiber mats enable efficient particulate matter capture while simultaneously providing antimicrobial and antiviral activity against bacteria (E. coli and S.
Edilton N. da Silva +9 more
wiley +1 more source